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Crisis response A crisis response committee has been set up in Banalia, as well as in Kisangani, the capital of Tshopo, to accelerate the outbreak control efforts. WHO has provided medical supplies in Banalia and plans to deploy more experts and resources. ÃÂÂWe are moving fast, delivering medicines and deploying experts to support the governmentâÂÂs efforts to bring the outbreak under control in the shortest possible time,â said online pharmacy lasix Dr Matshidiso Moeti, WHO Regional Director for Africa. Potentially fatal Over the years, major improvements have been made on treatments against , which are specific to the type of meningitis. The disease is transmitted through droplets of respiratory or throat secretions from infected people. Close and prolonged online pharmacy lasix contact or living in close quarters with an infected person facilitates the spread of the disease. Although people of all ages can catch meningitis, it mainly affects babies, children and young people. ÃÂÂWe are scaling up control measures within the community and rapidly investigating suspected cases in surrounding localities to treat patients and curb potentially widespread s,â said Dr Amédée Prosper Djiguimdé, WHO Representative in the Democratic Republic of the Congo. Meningitis belt More than 1.6 million people aged between 1 and 29 years were vaccinated during an extensive campaign in 2016 in Tshopo, which lies in the African meningitis online pharmacy lasix belt that runs across the continent from Senegal to Ethiopia and comprises 26 countries. The African meningitis belt is the most vulnerable globally to recurrent outbreaks. Outbreaks have occurred in several DRC provinces in the past. In 2009, an outbreak in Kisangani infected 214 people and caused 15 deaths online pharmacy lasix - a case fatality ratio of 8%. In November 2020, the World Health Assembly, the global health policy-setting body, approved a roadmap for a meningitis-free world by 2030, with three key objectives. Elimination of bacterial meningitis, reduction of treatment-preventable bacterial meningitis by 50% and deaths by 70%, as well as reduction of disability and improvement of quality of life after meningitis.. More than 260 suspected cases and buy lasix 100mg 129 deaths have been reported in Tshopo Province. A high case fatality ratio of 50 per cent, the UN health agency said on Wednesday.⯠Tests carried out by the Institut Pasteur in Paris, detected Neisseria meningitis. It is one of the most frequent strains buy lasix 100mg of the bacterial form of the disease, and it has the potential to cause large epidemics. WHO said that more than 100 patients are receiving treatment at home and in health centres in Banalia, the community affected by the outbreak.⯠Meningitis is potentially fatal and must be treated with antibiotics as soon as possible. Major improvements have also been made on treatments to treat the viral form of the disease, which is transmitted through the air by infected carriers. Although people of all ages can catch buy lasix 100mg the disease, it mainly affects babies, children and young people. Crisis response A crisis response committee has been set up in Banalia, as well as in Kisangani, the capital of Tshopo, to accelerate the outbreak control efforts. WHO has provided medical supplies in Banalia and plans to deploy more experts and resources. ÃÂÂWe are moving fast, delivering buy lasix 100mg medicines and deploying experts to support the governmentâÂÂs efforts to bring the outbreak under control in the shortest possible time,â said Dr Matshidiso Moeti, WHO Regional Director for Africa. Potentially fatal Over the years, major improvements have been made on treatments against , which are specific to the type of meningitis. The disease is transmitted through droplets of respiratory or throat secretions from infected people. Close and prolonged contact or living in close quarters with an infected buy lasix 100mg person facilitates the spread of the disease. Although people of all ages can catch meningitis, it mainly affects babies, children and young people. ÃÂÂWe are scaling up control measures within the community and rapidly investigating suspected cases in surrounding localities to treat patients and curb potentially widespread s,â said Dr Amédée Prosper Djiguimdé, WHO Representative in the Democratic Republic of the Congo. Meningitis belt More than 1.6 million people aged between 1 and 29 years were vaccinated during an extensive campaign in 2016 in Tshopo, which buy lasix 100mg lies in the African meningitis belt that runs across the continent from Senegal to Ethiopia and comprises 26 countries. The African meningitis belt is the most vulnerable globally to recurrent outbreaks. Outbreaks have occurred in several DRC provinces in the past. In 2009, an outbreak in Kisangani infected 214 people and caused 15 buy lasix 100mg deaths - a case fatality ratio of 8%. In November 2020, the World Health Assembly, the global health policy-setting body, approved a roadmap for a meningitis-free world by 2030, with three key objectives. Elimination of bacterial meningitis, reduction of treatment-preventable bacterial meningitis by 50% and deaths by 70%, as well as reduction of disability and improvement of quality of life after meningitis.. What may interact with Lasix?
This list may not describe all possible interactions. Give your health care provider a list of all the medicines, herbs, non-prescription drugs, or dietary supplements you use. Also tell them if you smoke, drink alcohol, or use illegal drugs. Some items may interact with your medicine. Lasix trade nameSOURCES http://lischke-atelier.de/2018/05/09/textiles-von-karin-lischke/ lasix trade name. Kate Zerbi, MS patient, Denver. Lauri Frenkel, founder, A PetâÂÂs Purpose, Madison, GA. American Kennel lasix trade name Club. ÃÂÂEverything You Need to Know About Emotional Support Animals,â âÂÂService Dogs 101 -- Everything You Need to Know.â U.S. Department of Transportation. ÃÂÂTraveling by https://eingrext.at/portfolio/test/ Air with lasix trade name Service Animals.â Humane Society. ÃÂÂTravel safely with your pet by car, airplane, ship or train.â Therapy Dogs International. ÃÂÂTherapy Dogs International (TDI ).â American Journal of Preventive Medicine. ÃÂÂVolunteering and Subsequent Health lasix trade name and Well-Being in Older Adults. An Outcome-Wide Longitudinal Approach.â U.S. Department of Justice. ÃÂÂCommonly Asked Questions About Service Animals in Places of Business.âÂÂ. SOURCES lasix street price buy lasix 100mg. Kate Zerbi, MS patient, Denver. Lauri Frenkel, founder, A PetâÂÂs Purpose, Madison, GA. American Kennel Club buy lasix 100mg. ÃÂÂEverything You Need to Know About Emotional Support Animals,â âÂÂService Dogs 101 -- Everything You Need to Know.â U.S. Department of Transportation. ÃÂÂTraveling by Air with Service Animals.â Humane Society buy lasix 100mg http://issihealth.com/homepage-6/. ÃÂÂTravel safely with your pet by car, airplane, ship or train.â Therapy Dogs International. ÃÂÂTherapy Dogs International (TDI ).â American Journal of Preventive Medicine. ÃÂÂVolunteering and Subsequent Health buy lasix 100mg and Well-Being in Older Adults. An Outcome-Wide Longitudinal Approach.â U.S. Department of Justice. ÃÂÂCommonly Asked Questions About Service Animals in Places of Business.âÂÂ. Lasix tablet onlineAcute Kidney Injury (AKI) as a result of ischaemia-reperfusion injury (IRI), is a lasix tablet online common cause of kidney damage especially in older individuals. In many forms of AKI, infiltrating pro-inflammatory lasix tablet online macrophages are critical mediators of tubular damage. Repeated episodes of AKI can lead to, or exacerbate, chronic kidney disease (CKD), and effective therapies for treatment or prevention are lacking. Most research into AKI is based on in vivo rodent lasix tablet online models of IRI, which are poor at replicating human risk factors (e.g. Ageing, diabetes and pre-existing CKD). 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The studentship is funded by the St Peters Trust and there will be opportunity for the student to access a wide range of scientific platforms and technologies. Any new therapeutic outcome in our models that attenuates injury could be further developed for clinical application through existing collaborations with the pharmaceutical industry.Studentship DescriptionHuman proximal tubular cells in lasix tablet online transwell co-culture with macrophages will be evaluated under conditions mimicking IRI in clinically-relevant scenarios viz. Repeated injury, lasix tablet online diabetes and aging. Cellular responses will be assessed for established markers of cell injury using a range of techniques, including LNA GapmeR RNA silencing, qPCR, RNASeq, fluorescence-activated cells sorting (FACS), confocal microscopy and multiplex secretome analysis. In particular, the importance of non-coding RNAs such as lasix tablet online long non-coding RNAs (LncRNAs) in renal IRI will be investigated. Novel findings will be validated in precision cut human kidney slices. Bioinformatical analyses including RNA interactome analysis, will be performed and data compared with published human, pre-clinical and in vitro data sets to provide a better understanding of the lasix tablet online pathophysiology of IRI. In addition, the models will be validated as platforms for therapeutic testing of novel compounds.For more information regarding the project and the research group, please contact. E.klootwijk@ucl.ac.uk and visit the UCL lasix tablet online website https://www.ucl.ac.uk/nephrology/.Applications should sent directly to Dr Enriko Klootwijk (e.klootwijk@ucl.ac.uk) and include a Curriculum Vitae (CV) and a cover letter. This should set out your previous academic or other experience relevant to the proposed research. Why you wish to undertake this research at UCL lasix tablet online. Your previous research or professional lasix tablet online training and what further training you think you will need to complete a PhD. And what ethical issues you will need to consider in undertaking this research. In addition, two references should be named lasix tablet online at the end of the statement. At least one reference must be from an academic referee who is in a position to comment on the standard of your academic work and suitability for postgraduate level study. Where appropriate, a second referee can provide comment on your professional experience.Person SpecificationApplicants must have lasix tablet online obtained at least an upper second-class honours degree (2:1, or equivalent qualification) in a relevant subject. They would be required to have an interest in renal pathophysiology, cell and molecular biology and bioinformatics. Applicants are expected to be highly motivated to pursue a PhD in medical sciences and are required lasix tablet online to work as part of a team.Practical experience in a relevant subject would be an advantage, although it is not essential. Some experience in programming (e.g. C+, C++, python, or R) and/or RNA sequence analysis would also be desirable.EligibilityEligibility criteria for UCL research degrees can lasix tablet online be found at. Https://www.ucl.ac.uk/prospective-students/graduate/research-degrees/entry-requirements This funding is limited to UK/EU nationals and is for 3 years. The stipend amount will be 2020/21 lasix tablet online. ã17,285, lasix tablet online 2021/22. ã17,631, 2022/23. ã17,983 plus Home/EU fees lasix tablet online and consumables.Please note. Applications from candidates who are not eligible will not be considered.Part-time and fixed-term for 24 monthsWe are seeking to appoint an ambitious and motivated Research Associate to undertake work on a funded research project, âÂÂSCONe. Scottish Clinical lasix tablet online Optometry and Ophthalmology e-NetworkâÂÂ. This post offers an opportunity to be involved in an exciting and cutting-edge research programme to establish a retinal image repository within Scotland. The Research Associate should have an optometry background and will work closely with the SCONe group to gather data relating to the on-site retinal imaging resource, method of data storage and business models of optometry practices in Scotland.This post is lasix tablet online 2 year fixed term (FTE 0.6). Working hours may vary.The post will be based within the Centre for Clinical Brain Sciences at the University of Edinburgh.SCONe particularly welcomes applications from candidates belonging to groups that have been traditionally underrepresented in the team. For more information on our lasix tablet online family-friendly policies please visit - www.ed.ac.uk/human-resources/policies-guidanceFor more information and to submit an application, please use the âÂÂapplyâ button below.www.vacancies.ed.ac.uk/pls/corehrrecruit/erq_jobspec_version_4.jobspec?. P_id=053099. Acute Kidney Injury (AKI) as a result of ischaemia-reperfusion injury (IRI), buy lasix 100mg is a common cause of kidney damage especially in older individuals. In many forms of AKI, infiltrating pro-inflammatory buy lasix 100mg macrophages are critical mediators of tubular damage. Repeated episodes of AKI can lead to, or exacerbate, chronic kidney disease (CKD), and effective therapies for treatment or prevention are lacking. Most research into AKI is based on in vivo rodent models of IRI, which buy lasix 100mg are poor at replicating human risk factors (e.g. Ageing, diabetes and pre-existing CKD). As a result there has been a striking failure of promising pre-clinical targets to translate to clinical efficacy and there is a buy lasix 100mg pressing need for alternative models to better understand AKI.The aim of the proposed study is to develop, characterize, and validate a novel in vitro model based on human kidney cells co-cultured with macrophages under conditions mimicking ischemia reperfusion, to provide new insights in the pathobiology of macrophage-tubular cell interactions in AKI. Interesting novel findings will be validated using an ex vivo co-culture system based on human kidney tissue slices and macrophages. This will also provide novel platforms for testing new therapeutics.Based in the Division of Medicine - Research Department of Renal Medicine, the student will have the buy lasix 100mg opportunity to work with leading academics and clinicians. The studentship is funded by the St Peters Trust and there will be opportunity for the student to access a wide range of scientific platforms and technologies. Any new therapeutic outcome in our models that attenuates injury could be further developed for clinical application through existing collaborations with the pharmaceutical industry.Studentship DescriptionHuman proximal tubular cells in transwell co-culture with macrophages will buy lasix 100mg be evaluated under conditions mimicking IRI in clinically-relevant scenarios viz. Repeated injury, buy lasix 100mg diabetes and aging. Cellular responses will be assessed for established markers of cell injury using a range of techniques, including LNA GapmeR RNA silencing, qPCR, RNASeq, fluorescence-activated cells sorting (FACS), confocal microscopy and multiplex secretome analysis. In particular, the importance of non-coding RNAs such as long buy lasix 100mg non-coding RNAs (LncRNAs) in renal IRI will be investigated. Novel findings will be validated in precision cut human kidney slices. Bioinformatical analyses including RNA interactome analysis, will be performed and data compared with published human, pre-clinical and in vitro data sets to provide a better buy lasix 100mg understanding of the pathophysiology of IRI. In addition, the models will be validated as platforms for therapeutic testing of novel compounds.For more information regarding the project and the research group, please contact. E.klootwijk@ucl.ac.uk and visit the UCL website https://www.ucl.ac.uk/nephrology/.Applications should sent directly to Dr Enriko Klootwijk (e.klootwijk@ucl.ac.uk) and include a Curriculum Vitae (CV) and a cover buy lasix 100mg letter. This should set out your previous academic or other experience relevant to the proposed research. Why you wish to undertake this research buy lasix 100mg at UCL. Your previous research or professional buy lasix 100mg training and what further training you think you will need to complete a PhD. And what ethical issues you will need to consider in undertaking this research. In addition, two references should buy lasix 100mg be named at the end of the statement. At least one reference must be from an academic referee who is in a position to comment on the standard of your academic work and suitability for postgraduate level study. Where appropriate, a second referee can provide comment on your professional experience.Person SpecificationApplicants must have obtained buy lasix 100mg at least an upper second-class honours degree (2:1, or equivalent qualification) in a relevant subject. They would be required to have an interest in renal pathophysiology, cell and molecular biology and bioinformatics. Applicants are expected to be highly motivated to pursue a PhD buy lasix 100mg in medical sciences and are required to work as part of a team.Practical experience in a relevant subject would be an advantage, although it is not essential. Some experience in programming (e.g. C+, C++, python, or R) and/or buy lasix 100mg RNA sequence analysis would also be desirable.EligibilityEligibility criteria for UCL research degrees can be found at. Https://www.ucl.ac.uk/prospective-students/graduate/research-degrees/entry-requirements This funding is limited to UK/EU nationals and is for 3 years. The stipend amount will buy lasix 100mg be 2020/21. ã17,285, buy lasix 100mg 2021/22. ã17,631, 2022/23. ã17,983 plus Home/EU fees and buy lasix 100mg consumables.Please note. Applications from candidates who are not eligible will not be considered.Part-time and fixed-term for 24 monthsWe are seeking to appoint an ambitious and motivated Research Associate to undertake work on a funded research project, âÂÂSCONe. Scottish Clinical Optometry buy lasix 100mg and Ophthalmology e-NetworkâÂÂ. This post offers an opportunity to be involved in an exciting and cutting-edge research programme to establish a retinal image repository within Scotland. The Research Associate should have an optometry background and will work closely with the SCONe group to gather data relating to the on-site retinal imaging resource, method of data storage and business models of optometry practices in Scotland.This post is 2 year fixed term (FTE 0.6). Working hours may vary.The post will be based within the Centre for Clinical Brain Sciences at the University of Edinburgh.SCONe particularly welcomes applications from candidates belonging to groups that have been traditionally underrepresented in the team. For more information on our family-friendly policies please visit - www.ed.ac.uk/human-resources/policies-guidanceFor more information and to submit an application, please use the âÂÂapplyâ button below.www.vacancies.ed.ac.uk/pls/corehrrecruit/erq_jobspec_version_4.jobspec?. P_id=053099. Can lasix be bought over the counterNIH research can lasix be bought over the counter could lead to new treatment strategies for stomach cancer Glucocorticoids and androgens promote a healthy stomach pit by inhibiting inflammation, left, while their absence promotes inflammation and SPEM seen in a diseased pit, right. SPEM glands are also much larger than healthy stomach glands. (Photo courtesy of Jonathan Busada, Ph.D./NIEHS) Scientists at the National Institutes of Health determined that stomach inflammation is can lasix be bought over the counter regulated differently in male and female mice after finding that androgens, or male sex hormones, play a critical role in preventing inflammation in the stomach. The finding suggests that physicians could consider treating male patients with stomach inflammation differently than female patients with the same condition. The study was published in Gastroenterology.Researchers at NIHâÂÂs National Institute can lasix be bought over the counter of Environmental Health Sciences (NIEHS) made the discovery after removing adrenal glands from mice of both sexes. Adrenal glands produce glucocorticoids, hormones that have several functions, one of them being suppressing inflammation. With no can lasix be bought over the counter glucocorticoids, the female mice soon developed stomach inflammation. The males did not. However, after removing androgens from the males, they exhibited the same can lasix be bought over the counter stomach inflammation seen in the females."The fact that androgens are regulating inflammation is a novel idea," said co-corresponding author John Cidlowski, Ph.D., deputy chief of the NIEHS Laboratory of Signal Transduction and head of the Molecular Endocrinology Group. "Along with glucocorticoids, androgens offer a new way to control immune function in humans."While this study provides insight into how inflammation is being regulated in males, Cidlowski said additional research is underway to understand the process in females. The scientist handling this can lasix be bought over the counter phase of research is co-corresponding author Jonathan Busada, Ph.D., assistant professor at West Virginia University School of Medicine in Morgantown. When Busada started the project several years ago, he was a postdoctoral fellow working in CidlowskiâÂÂs group.Whether inflammation is inside the stomach or elsewhere in the body, Busada said rates of chronic inflammatory and autoimmune diseases vary depending on sex. He said eight out of 10 individuals with autoimmune disease are women, and his long-term goal is to figure out how glucocorticoids and androgens affect stomach cancer, which is induced by chronic inflammation.The current research focused on stomach glands called pits, which are embedded in the lining of the stomach.Busada said the study showed that glucocorticoids and androgens act like brake pedals on the immune system and are essential for regulating can lasix be bought over the counter stomach inflammation. In his analogy, glucocorticoids are the primary brakes and androgens are the emergency brakes."Females only have one layer of protection, so if you remove glucocorticoids, they develop stomach inflammation and a pre-cancerous condition in the stomach called spasmolytic polypeptide-expressing metaplasia (SPEM)," Busada said. "Males have redundancy built in, so if something cuts the glucocorticoid can lasix be bought over the counter brake line, it is okay, because the androgens can pick up the slack."The research also offered a possible mechanism â or biological process â behind this phenomenon. In healthy stomach glands, the presence of glucocorticoids and androgens inhibit special immune cells called type 2 innate lymphoid cells (ILC2s). But in diseased stomach can lasix be bought over the counter glands, the hormones are missing. As a result, ILC2s may act like a fire alarm, directing other immune cells called macrophages to promote inflammation and damage gastric glands leading to SPEM and ultimately cancer."ILC2s are the only immune cells that contain androgen receptors and could be a potential therapeutic target," Cidlowski said.This press release describes a basic research finding. Basic research increases our understanding of human behavior can lasix be bought over the counter and biology, which is foundational to advancing new and better ways to prevent, diagnose, and treat disease. Science is an unpredictable and incremental process â each research advance builds on past discoveries, often in unexpected ways. Most clinical advances would can lasix be bought over the counter not be possible without the knowledge of fundamental basic research. To learn more about basic research, visit Basic Research â Digital Media Kit.Grant Numbers:ZIAES090057Fi2GM123974P20GM103434P20GM121322U54GM104942P30GM103488 Reference. Busada JT, Peterson KN, Khadka S, Xu, X, can lasix be bought over the counter Oakley RH, Cook DN, Cidlowski JA. 2021. Glucocorticoids and androgens protect from gastric metaplasia by suppressing group 2 innate lymphoid cell activation. Gastroenterology. Doi. 10.1053/j.gastro.2021.04.075 [Online 7 May 2021].CORVALLIS, Ore. àA team of Oregon State University scientists has discovered a new class of anti-cancer compounds that effectively kill liver and breast cancer cells. The findings, recently published in the journal Apoptosis, describe the discovery and characterization of compounds, designated as Select Modulators of AhR-regulated Transcription (SMAhRTs). Edmond Francis OâÂÂDonnell III and a team of OSU researchers conducted the research in the laboratory of Siva Kolluri, a professor of cancer research at Oregon State. They also identified the aryl hydrocarbon receptor (AhR) as a new molecular target for development of cancer therapeutics. ÃÂÂOur research identified a therapeutic lead that acts through a new molecular target for treatment of certain cancers,â Kolluri said. OâÂÂDonnell added. ÃÂÂThis is an exciting development which lays a foundation for a new class of anti-cancer therapeutics acting through the AhR.â The researchers employed two molecular screening techniques to discover potential SMAhRTs and identified a molecule â known as CGS-15943 â that activates AhR signaling and kills liver and breast cancer cells. Specifically, they studied cells from human hepatocellular carcinoma, a common type of liver cancer, and cells from triple negative breast cancer, which account for about 15% of breast cancers with the worst prognosis. ÃÂÂWe focused on these two types of cancers because they are difficult to treat and have limited treatment options,â said Kolluri, a professor in the Department of Environmental and Molecular Toxicology in the College of Agricultural Sciences. ÃÂÂWe were encouraged by the results because they are unrelated cancers and targeting the AhR was effective in inducing death of both of these distinct cancers.â The researchers also identified the AhR-mediated pathways that contribute to the anti-cancer actions of CGS-15943. Developing cancer treatments requires a detailed understanding of how they act to induce anti-cancer effects. The researchers determined that CGS-15943 increases the expression of a protein called Fas Ligand through the AhR and causes cancer cell death. These results provide exciting new leads for drug development, but human therapies based on these results may not be available to patients for 10 years, the researchers said. An editorial commemorating the 25th anniversary issue of the journal Apoptosis highlighted this discovery and the detailed investigation of cancer cell death promoted by CGS-15943. In addition to Kolluri and OâÂÂDonnell, who recently completed medical school and is an orthopaedic surgery resident at UC Davis Medical Center, other authors of the paper are. Hyo Sang Jang and Nancy Kerkvliet, both from Oregon State. And Daniel Liefwalker, who formerly worked in KolluriâÂÂs lab and is now at Oregon Health and Science University. Kolluri is also part of Oregon StateâÂÂs Linus Pauling Institute and The Pacific Northwest Center for Translational Environmental Health Research. Funding for the research came from the American Cancer Society, National Institute of Environmental Health Sciences, the U.S. Army Medical Research and Material Command, the Department of Defense Breast Cancer Research Program, Oregon State University and the National Cancer Institute.. NIH research could lead to new treatment strategies for stomach cancer Glucocorticoids and androgens promote a http://rabbitsunlimited.org/?page_id=133 healthy stomach pit by inhibiting inflammation, left, while their absence promotes inflammation and SPEM seen buy lasix 100mg in a diseased pit, right. SPEM glands are also much larger than healthy stomach glands. (Photo courtesy of Jonathan Busada, Ph.D./NIEHS) Scientists at the National Institutes of Health determined that stomach inflammation is regulated differently in male and female mice after finding that androgens, or male buy lasix 100mg sex hormones, play a critical role in preventing inflammation in the stomach. The finding suggests that physicians could consider treating male patients with stomach inflammation differently than female patients with the same condition. The study was published in Gastroenterology.Researchers at buy lasix 100mg NIHâÂÂs National Institute of Environmental Health Sciences (NIEHS) made the discovery after removing adrenal glands from mice of both sexes. Adrenal glands produce glucocorticoids, hormones that have several functions, one of them being suppressing inflammation. With no buy lasix 100mg glucocorticoids, the female mice soon developed stomach inflammation. The males did not. However, after removing androgens from the males, they exhibited the same stomach inflammation seen in the females."The fact that androgens are regulating inflammation is a novel idea," said co-corresponding author John Cidlowski, buy lasix 100mg Ph.D., deputy chief of the NIEHS Laboratory of Signal Transduction and head of the Molecular Endocrinology Group. "Along with glucocorticoids, androgens offer a new way to control immune function in humans."While this study provides insight into how inflammation is being regulated in males, Cidlowski said additional research is underway to understand the process in females. The scientist handling this phase of research is co-corresponding author Jonathan Busada, Ph.D., assistant professor at West Virginia University School of Medicine in Morgantown buy lasix 100mg. When Busada started the project several years ago, he was a postdoctoral fellow working in CidlowskiâÂÂs group.Whether inflammation is inside the stomach or elsewhere in the body, Busada said rates of chronic inflammatory and autoimmune diseases vary depending on sex. He said eight out of 10 individuals with autoimmune disease are women, and his long-term goal is to figure out how glucocorticoids and androgens affect stomach cancer, which is induced by chronic inflammation.The current research focused on stomach glands called pits, which are embedded in the lining of the stomach.Busada buy lasix 100mg said the study showed that glucocorticoids and androgens act like brake pedals on the immune system and are essential for regulating stomach inflammation. In his analogy, glucocorticoids are the primary brakes and androgens are the emergency brakes."Females only have one layer of protection, so if you remove glucocorticoids, they develop stomach inflammation and a pre-cancerous condition in the stomach called spasmolytic polypeptide-expressing metaplasia (SPEM)," Busada said. "Males have redundancy built in, so if something cuts the glucocorticoid brake line, it is okay, because the androgens can pick up the slack."The research also offered a possible mechanism â or biological process â behind this phenomenon buy lasix 100mg. In healthy stomach glands, the presence of glucocorticoids and androgens inhibit special immune cells called type 2 innate lymphoid cells (ILC2s). But in diseased stomach glands, buy lasix 100mg the hormones are missing. As a result, ILC2s may act like a fire alarm, directing other immune cells called macrophages to promote inflammation and damage gastric glands leading to SPEM and ultimately cancer."ILC2s are the only immune cells that contain androgen receptors and could be a potential therapeutic target," Cidlowski said.This press release describes a basic research finding. Basic research increases our understanding of human behavior and buy lasix 100mg biology, which is foundational to advancing new and better ways to prevent, diagnose, and treat disease. Science is an unpredictable and incremental process â each research advance builds on past discoveries, often in unexpected ways. Most clinical advances buy lasix 100mg would not be possible without the knowledge of fundamental basic research. To learn more about basic research, visit Basic Research â Digital Media Kit.Grant Numbers:ZIAES090057Fi2GM123974P20GM103434P20GM121322U54GM104942P30GM103488 Reference. Busada JT, Peterson KN, Khadka S, Xu, X, Oakley RH, Cook DN, Cidlowski buy lasix 100mg JA. 2021. Glucocorticoids and androgens protect from gastric metaplasia by suppressing group 2 innate lymphoid cell activation. Gastroenterology. Doi. 10.1053/j.gastro.2021.04.075 [Online 7 May 2021].CORVALLIS, Ore. àA team of Oregon State University scientists has discovered a new class of anti-cancer compounds that effectively kill liver and breast cancer cells. The findings, recently published in the journal Apoptosis, describe the discovery and characterization of compounds, designated as Select Modulators of AhR-regulated Transcription (SMAhRTs). Edmond Francis OâÂÂDonnell III and a team of OSU researchers conducted the research in the laboratory of Siva Kolluri, a professor of cancer research at Oregon State. They also identified the aryl hydrocarbon receptor (AhR) as a new molecular target for development of cancer therapeutics. ÃÂÂOur research identified a therapeutic lead that acts through a new molecular target for treatment of certain cancers,â Kolluri said. OâÂÂDonnell added. ÃÂÂThis is an exciting development which lays a foundation for a new class of anti-cancer therapeutics acting through the AhR.â The researchers employed two molecular screening techniques to discover potential SMAhRTs and identified a molecule â known as CGS-15943 â that activates AhR signaling and kills liver and breast cancer cells. Specifically, they studied cells from human hepatocellular carcinoma, a common type of liver cancer, and cells from triple negative breast cancer, which account for about 15% of breast cancers with the worst prognosis. ÃÂÂWe focused on these two types of cancers because they are difficult to treat and have limited treatment options,â said Kolluri, a professor in the Department of Environmental and Molecular Toxicology in the College of Agricultural Sciences. ÃÂÂWe were encouraged by the results because they are unrelated cancers and targeting the AhR was effective in inducing death of both of these distinct cancers.â The researchers also identified the AhR-mediated pathways that contribute to the anti-cancer actions of CGS-15943. Developing cancer treatments requires a detailed understanding of how they act to induce anti-cancer effects. The researchers determined that CGS-15943 increases the expression of a protein called Fas Ligand through the AhR and causes cancer cell death. These results provide exciting new leads for drug development, but human therapies based on these results may not be available to patients for 10 years, the researchers said. An editorial commemorating the 25th anniversary issue of the journal Apoptosis highlighted this discovery and the detailed investigation of cancer cell death promoted by CGS-15943. In addition to Kolluri and OâÂÂDonnell, who recently completed medical school and is an orthopaedic surgery resident at UC Davis Medical Center, other authors of the paper are. Hyo Sang Jang and Nancy Kerkvliet, both from Oregon State. And Daniel Liefwalker, who formerly worked in KolluriâÂÂs lab and is now at Oregon Health and Science University. Kolluri is also part of Oregon StateâÂÂs Linus Pauling Institute and The Pacific Northwest Center for Translational Environmental Health Research. Funding for the research came from the American Cancer Society, National Institute of Environmental Health Sciences, the U.S. Army Medical Research and Material Command, the Department of Defense Breast Cancer Research Program, Oregon State University and the National Cancer Institute.. Lasix protocolThis article lasix protocol contains affiliate links http://herlifefranchise.com/how-to-buy-ventolin-online/ to products. Discover may receive a commission for purchases made through these links.Our liver plays a major role in supporting our overall health, including helping with the metabolic process, digestion, and proper blood circulation, as well as cleansing the body of harmful toxins. However, most people damage their livers without even knowing it, lasix protocol with things like drinking too much alcohol, eating processed or fried foods, or even being just a little overweight. ThatâÂÂs why many people have been turning to natural liver health supplements. A good quality liver supplement is an effective solution to help repair liver damage and optimize liver functioning. Ranking the Best Liver Health Supplements On The Market We reviewed the top brands and found the lasix protocol best 5 liver supplements on the market today. See our full list below. 1MD LiverMD Live Conscious LiverWell Gaia Herbs Liver Cleanse 1. 1MD LiverMD LiverMD delivers 6 powerful, clinically studied ingredients in one groundbreaking, exclusive 1MD formula to help purify lasix protocol and optimize liver function for better energy, metabolism, and overall health. This doctor-formulated liver support stands out because it includes EvnolMax, which is a clinical strength tocotrienol, and Siliphos, the bioavailable active ingredient in milk thistle. LiverMD is also made with zinc, selenium, and other ingredients that work to help detox and repair your liver. Additionally, 1MD offers a 90-day, risk-free, money-back guarantee, proving the company stands behind lasix protocol its products. BUY HERE 2. Live Conscious LiverWell LiverWellâÂÂs formula combines optimal liver health ingredients, including clinically studied milk thistle, NAC, and alpha lipoic acid to name a few. Their product is lasix protocol shown to aid liver function, metabolism, and whole-body detoxification. LiverWell is best for those who need to reduce the effects of environmental toxins and struggle with metabolic issues. LiverWellâÂÂs use of powerful antioxidants has also been shown to reduce and repair damage done to liver and kidney health from free radicals in the body. Beyond that, LiveWell offers a comprehensive 365-day return policy, so everyone can try their products lasix protocol completely risk-free. BUY HERE 3. Gaia Herbs Liver Cleanse Liver CleanseâÂÂs unique proprietary blend covers a vast range of liver supporting nutrients that are all-natural and entirely herbal. While it does contain milk thistle, it lacks several key ingredients, such as zinc, lasix protocol selenium, or any form of Vitamin E. This limits its ability to support your liver health. The transparent labeling showcases all the ingredients included in its proprietary formula. Gaia Herbs takes a simple approach to producing a good quality liver support supplement for a low price range.Ask any nutritionist and they'll tell you that our health is a reflection of the lifestyle we lead and what we lasix protocol put on our plates. The food we eat not only satisfies our hunger. It also fuels our bodies with energy to carry on. In todayâÂÂs fast-paced lasix protocol life, there's limited time to make elaborate home-cooked meals. It's no wonder that 80 percent of Americans' total calorie consumption is thought to come from store-bought foods and beverages. Many of these food items are considered ua-processed, causing a growing rate of concern for human health among scientists.Breaking Down Ua-Processed FoodsYou may be wondering what exactly ua-processed foods are. The concept of processing refers to changing food from its natural lasix protocol state, according to Harvard Health Publishing. Methods of accomplishing this include canning, smoking, pasteurizing and drying. Ua-processed foods take processing one step further by adding multiple ingredients such as sugar, preservatives and artificial flavors and colors. Commercially prepared lasix protocol cookies, chips and sodas are just a few of many examples of foods that fall into the highly processed category. In order to further understand ua-processed foods, we must first explore the different levels of food processing. The term ua-processed was first coined by Carlos Monteiro, a professor of nutrition and public health at the University of Sao Paulo, Brazil. Monteiro also lasix protocol created a food classification system called NOVA that has become a popular tool in categorizing different food items. The NOVA Food Classification system contains four different groups:Unprocessed/Minimally Processed Foods. Think 100 percent natural and healthy. This group includes lasix protocol foods such as fruits, vegetables, eggs, meats and milk. Unprocessed foods are considered completely natural and are typically obtained directly from plants and animals. Minimally processed foods are also natural foods that have had very minor changes such as removal of inedible parts, fermentation, cooling, freezing, and any other processes that won't add extra ingredients or substances to the original product.Processed Culinary Ingredients. This group has everything to do with flavor and typically contains ingredients such lasix protocol as fats and aromatic herbs that are extracted from natural foods. These ingredients are then used in homes and restaurants to season and cook items such as soups, salads and sweets. Many of these extracted ingredients can also be stored for later use. Processed Foods lasix protocol. Most processed foods contain at least two or three added ingredients such as salt, sugar and oil. Think of this group as a combination of the first two groups. In other words, processed culinary ingredients or lasix protocol flavors that are added to natural foods. Examples include fruits in sugar syrup, bacon, beef jerky and salted nuts. Ua-Processed Foods. Last and least healthy on the NOVA scale are ua-processed lasix protocol foods. This group is considered highly processed due to a large amount of added ingredients. Nova typically classifies this group as industrial formulations made entirely or mostly from substances such as oils, fats, sugar, starch lasix protocol and proteins as well as flavor enhancers and artificial colors that make these foods appear more attractive. Frozen items such as pre-prepared burgers or pizzas, candies, sodas, chips and ice cream are a few examples. On a daily basis, the ua-processed category is not the best source of your nutritional intake. But there's still hope for our frozen pizza and chocolate lovers lasix protocol. Caroline Passerrello, spokesperson for the Academy of Nutrition and Dietetics, suggests that there may be a place on our plates for processed foods. Everything in ModerationIt's often said that most things are OK in moderation. But does this saying ring true lasix protocol for ua-processed foods?. According to Passerrello, ua-processed foods like cookies, chips and sodas are more energy than nutrient-dense. This means that while the energy and calories are present, the nutrients we require like vitamins and minerals are often lacking. This can become a cause for concern because our bodies require both energy and nutrients to function properly.A 2017 study that lasix protocol followed the dietary intakes of 9,317 participants found that Americans were eating ua-processed foods at alarming rates. Foods, in this case, were classified according to the NOVA scale. The results of the study showed that on average more than half of the calories of the participants came from ua-processed foods. These foods failed to deliver proper lasix protocol nutrients. Participants that consumed more ua-processed food lacked proper protein, calcium, fiber, potassium, and vitamins A, C, D and E in their diets. In contrast, participants that consumed higher amounts of unprocessed or minimally processed foods had a better overall diet with adequate amounts of the different nutrients.So, a balanced diet of the different food groups may just be the way to go. But what happens when we lasix protocol overindulge in ua-processed foods on a regular basis?. Because ua-processed foods are typically filled with sugar and fat, they've been linked to numerous health risks including obesity, heart disease and stroke, type-2 diabetes, cancer and depression.Passerrello explains that overconsumption of highly processed foods over time can also lead to vitamin and mineral deficiencies. In addition, processed foods tend to have higher amounts of sodium, which is often used to extend their shelf life. Consuming too much sodium can lead to feelings of dehydration and cause muscle twitches.The health risks lasix protocol associated with overconsumption of ua-processed foods can easily pile up, but luckily, there are some healthy alternatives that we can choose to incorporate into our diet. Eat This Not ThatCutting down on ua-processed foods definitely seems like a good start to a healthy and balanced diet, but it's only the first step. "It's not just the ua-processed food itself that is the concern, but what else we are, or are not, eating â as well as what our bodies need and ultimately, what foods we have access to on a regular basis," says Passerrello.Health and nutrition can vary from person to person, so there is definitely no hard and fast rule as to what goes and what stays. However, Passerrello advises that if you are in a position in life with your time, taste and budget lasix protocol to make a choice between an ua-processed food item and a minimally processed food item, you should typically opt for the minimally processed food.Yes, frozen dinners may be an easy option after a long day of work. However, an easy alternative that can save time could be meal prepping in advance. A homemade alternative such as a simple rice dish or burritos can be easy to make in batches and store away for the week. Another simple way to slowly decrease your intake of processed foods is lasix protocol to check food labels for excess amounts of salt or sugar. Instead of sodas, Passerrello suggests opting for orange juice or milk that are fortified with calcium and vitamin D.Ultimately, choosing healthy foods is a matter of providing your body with the proper nutrients it needs while also incorporating your personal tastes and preferences. A handful of chips and a frozen pizza may not be the healthiest treat, but they won't do serious damage as long as ua-processed foods aren't your main and only form of nutrients.Like many people, Stephanie Holm made holiday cookies with her family last year. Her daughter lasix protocol found a recipe on the internet, and the two of them set to making them in the kitchen of their apartment.Together, they mixed the dough, rolled it out, put the cookies on a pan and popped it in the oven â âÂÂliterally covered in sprinkles on the outsideâ¦cute, and very delicious,â says Holm, a pediatric environmental medicine specialist at UC San Francisco.But as the cookies baked, Holm noticed that the cute sugary coating burned a little in the oven, though not enough to ruin the cookies. Then Holm heard her daughter exclaim, âÂÂMama, itâÂÂs purple!. àand she saw that the air quality sensor she keeps in their apartment had indeed turned from green (good air quality) to purple (very unhealthy). Could a single batch of slightly singed cookies have been to blame? lasix protocol. What happened with HolmâÂÂs cookies wasnâÂÂt a fluke. All cooking releases a complex mixture of chemicals, some of which would be classified as unhealthy pollutants. As for whether cooking is hazardous to lasix protocol your health â the short answer is, it depends. But generally, if you have good ventilation, you should be fine.âÂÂWe all cook, and the average life expectancy is 78 or 79 years old. So we shouldnâÂÂt get too worried,â says Delphine Farmer, an atmospheric chemist at Colorado State University. ÃÂÂBut it is an opportunity to think about how to reduce your exposure to pollutants.âÂÂOut of the Frying PanFarmerâÂÂs research found that cooking releases a mixture lasix protocol of hundreds of different chemical compounds into the air. Every ingredient gives off its own unique blend of particles and gases. Proteins in meat can break down and give off ammonia. Roasting can lasix protocol produce isocyanates. Oils from frying and sautéing can aerosolize (thatâÂÂs how your counters end up with a fine layer of grease on them). The airborne molecules can continue to react and change as they drift around your kitchen and bump into each other.âÂÂYou can see some of these really interesting compounds,â Farmer says. ÃÂÂBut are they lasix protocol at levels that are toxic?. We don't know.â Part of the uncertainty when it comes to health effects comes from the fact that most air quality studies and standards are based on outdoor air â despite our world where people today spend an estimated 90 percent of their time indoors. While Canada and the World Health Organization have indoor air quality guidelines, the U.S. Does not.In general, indoor lasix protocol air chemistry fluctuates a lot more than outdoor air. The average air quality can be good, but as Holm and her daughter experienced, some activities â like cooking and cleaning â can cause dramatic changes. Pollutant levels will spike in the kitchen while cooking is actively happening and then drift back down as the airborne molecules disperse.âÂÂThe pattern of exposure is different. And we really don't have great scientific data on what the difference of that pattern of exposures means for people's health.â Holm says.Acquiring that scientific data lasix protocol is no easy task. Variables that can affect cooking fumes and their contents include how often a person cooks, what they cook, how they cook it, what kind of appliance they use, what kind of ventilation they have and maybe even the type of pots and pans they use, says Iain Walker, an engineer at Lawrence Berkeley National Lab who studies home air quality and ventilation. The best researchers can do is try to gauge the relative impact of each factor. Gas stove lasix protocol or electric?. Boiling or frying?. Meat lasix protocol or vegetables?. Nonstick pan or stainless steel?. Into the FireThe main pollutant of concern linked to cooking is particulate matter. This catchall term refers to a complex lasix protocol mix of microscopic solid bits and uafine liquid droplets that could be made up of hundreds of different chemical compounds. The chemistry doesnâÂÂt matter nearly as much as the size. Particles smaller than 10 microns (less than 1/5 the width of a human hair) can make their way into the lungs and lodge there. Even smaller particles can make their way into the bloodstream.Particulate matter is the reason you donâÂÂt want to breathe in smoke or lasix protocol car exhaust. Chronic exposure to high levels of particulate matter exacerbates asthma, but also makes it more likely that a child will develop asthma, says Holm. ItâÂÂs also linked to changes in childhood growth, metabolism and brain development, and itâÂÂs classified as a carcinogen by the WHO.All cooking produces some particulate matter in the form of aerosols and tiny bits of char generated from food and dust being heated up. If you can smell burning, youâÂÂre likely breathing in quite a bit of particulate lasix protocol matter. ÃÂÂAnything with a red-hot element is going to generate particles,â says Walker. That includes most stovetops, ovens and even small appliances like toasters. Frying and lasix protocol roasting cook methods both produce a lot more particulate matter than boiling or steaming. And fatty foods give off more than veggies.Gas stoves are particularly bad for indoor air quality. Not only do they produce more particulate matter by virtue of creating an open flame, but the actual fossil fuel combustion also generates other gases, such as carbon dioxide and nitrogen dioxide. From a health perspective, the thing that raises the biggest concern in this scenario is lasix protocol nitrogen dioxide.Nitrogen dioxide, like particulate matter, contributes to breathing problems like asthma and is regulated in outdoor air. The gas has also been linked to heart problems, lower birth weight in newborns and shorter lifespans for people who are chronically exposed.A 2016 study from Lawrence Berkeley National Lab found that simply boiling water on a gas stove produces nearly twice the amount of nitrogen dioxide as the EPAâÂÂs outdoor standard. Considering that about a third of American homes use natural gas for cooking, thatâÂÂs a lot of potential exposure.âÂÂSomehow, we've just become used to an unvented fossil fuel device in our homes,â says Brady Seals, who manages the carbon-free buildings program at the Rocky Mountain Institute, a clean energy think tank. She wants to raise lasix protocol awareness of nitrogen dioxideâÂÂs health risks as a way to discourage natural gas use in homes. And sheâÂÂs not alone in this mission. The Massachusetts Medical Society passed a resolution in 2019 to recognize the link between gas stoves and pediatric asthma. Several cities in California, including San Francisco, have passed bans on natural gas in new construction, citing both climate and health hazards.If you have a gas cooktop, Seals and lasix protocol Walker recommend swapping it out for an electric one if you have the means and ability to do so. ÃÂÂNot only are you reducing carbon impact [on the environment], but you can have a healthier home if you get rid of combustion appliances,â Walker says.The best option from both an energy-efficiency and air-quality perspective, he says, is an induction stove, which uses magnets to transfer heat directly to your pots and pans. No red-hot elements means less particulate matter. If you canâÂÂt replace your gas lasix protocol stove, Seals recommends a plug-in induction cooktop.Vented AirRealistically, few people are going to swear off stir frying or using their oven for the sake of producing less particulate matter. ÃÂÂEverybodyâÂÂs going to cook what theyâÂÂre going to cook,â says Farmer, noting that people use whatever kitchen appliances they have. ThatâÂÂs why all these experts stress the importance of good ventilation.Holm was part of a 2018 study looking at particulate matter in the homes of children with asthma. One of the most lasix protocol surprising findings. In homes that never used a range hood or range fan, people were exposed to unhealthy levels of particulate matter for roughly 10 percent more time than in homes that used range ventilation.Walker, the ventilation expert, recommends that people should use a high setting on their kitchen range hood whenever possible, since the quieter low settings capture only about half of pollutants. Since most range hoods donâÂÂt extend over the front burners, you might want to consider using the back burners, especially if you have a gas stove. Walker also advises that people keep the ventilation on for about 15 minutes lasix protocol after theyâÂÂre done cooking. ThatâÂÂs about how long it takes for all of the air in the room to be replaced. But that only applies if your vent is sending fumes outside, which is not often the case.Unless you have a new, higher-end kitchen and stove, your built-in range ventilation might essentially be a fan. ItâÂÂs just pushing the fumes around the room, which helps disperse the concentration lasix protocol of pollutants more quickly but doesnâÂÂt actually remove them from your house. Many homes and apartments, including HolmâÂÂs, donâÂÂt even have that option. In that case, Holm recommends opening some windows if the outside air quality is good, or using a portable air purifier with a HEPA filter.In the end, there are still a lot of unknowns about how cooking fumes affect us. To some extent, we simply have to accept them as a byproduct of enjoying our favorite foods, much like we accept pet hair as a part of having lasix protocol a furry friend. ÃÂÂYou start realizing how pollutants are a part of our life,â Seals says. ÃÂÂLetâÂÂs reduce pollution wherever we can. But IâÂÂm lasix protocol not going to give up my dog and IâÂÂm not going to stop cooking.âÂÂ[Correction. A previous version of this story erroneously stated the findings of Holm's 2018 air quality study and the type of portable air purifier that Holm recommends using in homes. We apologize for the errors, which have been corrected in this current version.]A happy accident with a chocolate bar led to one of the most reliable kitchen appliances around today. Engineer Percy lasix protocol Spencer was standing in front of a device emitting high-frequency radio waves when the chocolate in his shirt pocket began to melt. The change led him and his colleagues to investigate what electromagnetic radiation could do to food, and the microwave was born in 1947.Since its earliest days, the technology has gotten smaller and lighter, and the kind of radiation used has shifted. SpencerâÂÂs discovery happened with radio waves, and the devices now rely on microwave radiation to cook our meals. Despite the changes â and how permanent a fixture microwaves have lasix protocol become in households â some people are still uneasy around the devices and worry about potential health effects. ÃÂÂAs a professor working in this area, safety is important to me,â says Vijaya Raghavan, a bioresource engineer at McGill University, who studies how industrial microwave settings can pasteurize and sterilize foods. Luckily, a lot of the safety concerns are handled by regulations, and there are simple ways for people to minimize the very small risks they face.Microwaves Bring the HeatMicrowaves are a kind of radiation, just like infrared, visible light, and x-rays. They are also lasix protocol relatively large. In terms of size and speed, microwaves are more like radio waves than they are the kind of light we see. Put to work inside kitchen appliances, the radiation lasix protocol is useful for cooking food fast. Microwaves emit from one side of the appliance while itâÂÂs running and bounce around, reflecting off the metal interior and going into your meal. There, microwaves force all the water molecules in your food to move. The spinning water molecules generate heat and voila â your leftovers, vegetables or frozen dinner gets cooked.When lasix protocol it comes to making water molecules spin and create heat, microwaves donâÂÂt discriminate. TheyâÂÂll do the same to your arm or leg, which is why microwave exposure can be dangerous. Exposure can burn skin. Eyes and testicles are particularly vulnerable, according to the Food and Drug Administration, because thereâÂÂs relatively lasix protocol little blood flow in the area to carry away the building heat. Highly-Controlled and Low RiskHowever, microwave burns only happen after someone has had a lot of exposure to the radiation â which is not something that will happen from your microwave oven. For one, microwaves can only operate if the door is closed, per FDA requirements. As soon as it opens, lasix protocol the radiation production stops. Any microwaves that were still within the device dissipate into the air right away, Raghavan says. Theoretically, a tiny bit of the microwaves could leak out of any cracks, like where the door shuts. But the lasix protocol FDA regulates seeping radiation, too. The amount of microwave radiation the agency lets the kitchen appliances emit is significantly less than how much cell phones are allowed to release â and the levels our smartphones can generate are also considered safe. And because any radiation coming out of an operating microwave starts to fall apart very quickly, someone would have to be standing practically up against the microwave for a long time for the rays to cause any damage. Sure, the farther away from the microwave you are, the safer it is, lasix protocol Raghavan says. ÃÂÂBut if youâÂÂre certain that a microwave unit is being used, why do you want to stand next to it anyways?. ÃÂÂIn his own lab, Raghavan uses all kinds of microwave ovens to see how they can help with industrial food preparation. He often buys standard microwaves most people put in their homes and reworked them to create the wavelength frequency he lasix protocol needs. Raghavan also keeps track of how much power is generated in the first place as well as how much of the microwaves are absorbed by the food or reflected. Even in this laboratory setting, he and his colleagues donâÂÂt wear protective gear. Instead, they put leakage meters near lasix protocol the devices. People at home probably donâÂÂt need to stand right next to the microwave, as Raghavan points out. Also, donâÂÂt run it without anything inside. The microwaves will bounce back and damage the internal mechanisms that help transmit the microwaves, Raghavan lasix protocol says. And if you find your microwave keeps running once you open the door, remove it and get a new model â you donâÂÂt want to be Percy Spencer and find that radiation is melting your pocket chocolate.Part one of this article began with a light-hearted anecdote about Count Volta sticking electrodes in his ears. Part two takes a more serious tone. Here, we address the reasons why cochlear lasix protocol implants arenâÂÂt available to everyone, and why they are nearly inaccessible to those who need them most in the developing world. The most pressing barriers that prevent adults and children in developing countries from accessing the benefits of cochlear implants are plain enough. (1) the high cost of cochlear implant components. (2) the complexity and skill level required to perform the surgery lasix protocol. And (3) the lack of local post-operative rehab services and expertise. Fortunately, thereâÂÂs a light at the end of the tunnel. In part two of this article, we look at the tremendous efforts of nonprofit groups to overcome these barriers to lasix protocol cochlear implants in developing countries. We also look at an experimental (yet controversial) approach to cochlear implants that could dramatically reduce the cost and complexity of implant components and surgeries. Why Access to Cochlear Implants Is So Important for Children Cochlear implants can offer life-transforming help to adults with hearing loss, but they are even more important for children. ThatâÂÂs because children with hearing loss have a limited period of time lasix protocol in which to develop speech and listening skills. If a hearing problem isnâÂÂt addressed with hearing aids or cochlear implants by the age of 3 (and preferably earlier), children with serious hearing conditions may not be able to develop auditory and speech skills naturally. Without listening and spoken language skills, it is more difficult for children with deafness and profound hearing loss to attend mainstream school or fully participate in their hearing communities. Tragically, many of these children in developing lasix protocol nations are miscategorized as intellectually disabled â when in fact, there is a shining, beautiful mind hidden behind their inability to communicate. Photo Courtesy of the Global Foundation For Children With Hearing Loss According to Paige Stringer, Executive Director of the Global Foundation For Children With Hearing Loss (GFCHL). ÃÂÂIt is essential that hearing loss be identified as early as possible in newborns and young children so they can get the hearing technology and early intervention support they need to learn to listen and speak. For a child to develop lasix protocol on par with typically hearing peers in the areas of speech, language, and audition, they must have access to the sounds of speech. Early access to hearing aids or cochlear implants is key for successful outcomes.â A landmark 2010 study echoes StringerâÂÂs perspective by confirming what most in the hearing and speech-language professions already knew. The study found that children who receive cochlear implants before the age of 18 months achieved a speaking ability closer to that of hearing children. In contrast, those who received cochlear implants after the age of 3 continued to exhibit certain gaps in speaking ability compared lasix protocol to children without hearing loss. In developing countries, where access to cochlear implants and hearing aids is scarce, some deaf children may be able to attend schools where they can learn sign language and benefit from a specialized curriculum. But children in rural, undeveloped areas donâÂÂt tend to have this option. Without cochlear implants, lasix protocol access to affordable hearing aids, or proper schooling, these children may not be able to develop their language and communication skills in a mainstreamed environment. To say that these children face severe discrimination, social isolation, and extreme socio-economic challenges as a result of their hearing difficulties would be an understatement. Image source. BBC When lasix protocol children are born with hearing impairment and deafness in developed countries like the United States or the United Kingdom, technologies, therapies, and educational opportunities are more readily available and help to remove the barriers to living a normal life. These children have the potential to grow up without impediments as developing children typically do. Why Are Cochlear Implants Difficult to Access in Developing lasix protocol Countries?. There are three main reasons why cochlear implants are difficult to access in developing countries. (1) the cost of the components and surgeries. (2) the complexity and surgical skill lasix protocol required to perform the procedures. And, (3) the need for post-operative rehabilitation services. (1) The High Cost of Cochlear Implant Components The cost of cochlear implant components and surgeries depends on a number of factors, but one thing is certain. The prices far lasix protocol exceed what the average person in a developing country can afford. In the United States, the components alone â without factoring in surgical costs â can exceed $25,000 per ear, and total costs with surgery can exceed $80,000 per ear. In developed nations, private or national insurance usually covers these costs, so access isnâÂÂt an issue. In many Asian, African, and Latin American countries, the cost of cochlear lasix protocol implant components is less, but the prices are still prohibitively high. In the article, âÂÂThe Challenges of Starting a Cochlear Implant Programme in a Developing Country,â Dr. Kumaresh Krishnamoorthy writes that Cochlear Implant components cost from $12,000 to $25,000 in India. With surgery, total costs come to $17,000 lasix protocol to $29,500. If you consider that the average Indian salary is $2,120 per year â and that these individuals are living paycheck to paycheck â itâÂÂs easy to see why cochlear implants are absolutely unaffordable for most Indians without any available government or insurance financial support. According to Stringer. ÃÂÂThere are also the ongoing costs associated with cochlear implants after surgery â which includes a lifelong commitment to paying lasix protocol for post-op rehabilitation, replacement parts, servicing, and upgrades. Many families focus on the cost of the initial device and surgery, but they donâÂÂt have the means to pay for these ongoing costs.â As Krishnamoorthy points out. ÃÂÂCochlear implants are a proven auditory rehabilitative option for individuals with severe to profound sensorineural hearing loss, who otherwise do not benefit from hearing aids. Nevertheless, only a small percentage of these individuals receive cochlear implants, and cost remains a lasix protocol leading prohibitive factor, particularly in developing countries [â¦] the technology is virtually unavailable to the masses.â Unfortunately, even though many developing countries have government-sponsored cochlear implant programs, most do not have enough surgeons or facilities â or rehabilitation support post-surgery â to service all of the people who need them. (2) The Complexity and Skill Level Required to Perform Cochlear Implant Surgeries Once fully trained, a neurotologist can safely perform a cochlear implant procedure, but the surgical training is long, involved, and expensive â and itâÂÂs only available in developed countries. As a result, there are not enough surgeons in developing countries who can safely perform cochlear implant procedures. Image Source lasix protocol. Blausen.com staff (2014). ÃÂÂMedical gallery of Blausen Medical 2014âÂÂ. WikiJournal of Medicine lasix protocol 1 (2). DOI:10.15347/wjm/2014.010. ISSN 2002-4436. When you see the lasix protocol steps involved, itâÂÂs easy to understand the complexity of the procedure. Administer general anesthesia. General anesthesia is required during the two- to four-hour procedure. Make lasix protocol an incision behind the ear. The surgeon makes an incision behind the ear to expose the mastoid bone. Identify the facial nerves. The surgeon finds the facial nerves and drills an opening between them through the mastoid bone to expose the cochlea lasix protocol. Place the electrode array. The surgeon opens the cochlea and threads the electrode array into the cochlea. Place the receiver lasix protocol. The surgeon makes a shallow indentation into the skull behind the ear and fixes the round, flat receiver into the bone just beneath the ear. Close the incisions. The surgeon closes the incisions and the procedure is lasix protocol complete. Considering these steps, the cochlear implant procedure is neither âÂÂsimpleâ nor âÂÂeasyâ to perform. It requires general anesthesia, drilling through the mastoid bone, and the removal of a portion of the skull. There is also the risk lasix protocol of facial nerve damage. While the use of surgical robots for cochlear implant procedures could reduce the skill requirement, this technology is still largely inaccessible in developing countries. As we will discuss in further detail below, there is the possibility that an experimental cochlear implant design could one day reduce the cost and surgical complexity associated with this technology. (3) The Need for Post-Operative Rehabilitation and Training Beyond the cost and complexity of cochlear implant lasix protocol surgeries, implant recipients need several months â or years in the case of infants and young children â of training as they learn to recognize sounds and understand speech. For children, speech-language therapy is particularly important. This training requirement often prevents those living in rural areas from getting cochlear implants â simply because they cannot access an in-person therapist for post-op rehab and speech-language training. Stringer from GFCHL offered lasix protocol the following perspectives on this. ÃÂÂCochlear implant technology is not a stand-alone solution. It is an intensive medical device that lasix protocol needs a lot of support. CIs are not like glasses where you put them on and instantly see better. A CI is just a tool to enable access to the sounds of speech. There is a great deal of rehabilitation lasix protocol involved after the CI surgery, particularly in young children, to fully benefit from it.â Getting cochlear implants to those who need them isnâÂÂt just a question of funding and sourcing surgeons. To make this technology available to more people in developing countries, national governments also need to conquer the serious logistical challenge of building a medical infrastructure that (1) has enough skilled surgeons and surgical facilities to serve everyone. And (2) has enough local training facilities where cochlear implant recipients can receive post-operative rehab and speech-language therapy. (4) The Lack of Awareness Surrounding the Benefits of Cochlear Implants There is also a lasix protocol lack of awareness surrounding (1) the need to screen babies and young children for signs of deafness, and (2) the benefits of cochlear implants and hearing aids when treating deafness and other hearing conditions. Without a general understanding of these issues, children born with hearing loss may never be identified â and even if they are identified, parents may not be aware that treatments and therapies are available. As for adults with hearing loss, they also might not realize that they are suffering from hearing loss â and if they do realize it, they might not know that a pair of hearing aids or cochlear implants can dramatically improve their lives. Incidentally, this lack of awareness is also a problem in lasix protocol the developed world, but adults â no matter where they are â can quickly assess their level of hearing loss by taking a free online hearing test. If youâÂÂre curious to check your hearing, hereâÂÂs a free, 5-minute hearing test from MDHearingAid. Overcoming the Challenges of Cochlear Implant Access The most common approach to overcoming the lack of access to cochlear implants is to increase nonprofit support and international aid for government cochlear implant programs. This involves helping lasix protocol developing nations overcome the logistical challenges of sourcing surgeons, establishing surgical and post-operative facilities, and educating the public on hearing loss treatment options. A second approach to increasing access involves a radical rethinking of the technology and its surgical techniques. By redesigning cochlear implants to be more affordable â and making surgeries simpler and less invasive â overcoming the cost and logistical challenges of cochlear implants becomes a great deal easier. (1) Nonprofit Efforts to Boost Cochlear Implant Access in Developing Countries There arenâÂÂt many organizations lasix protocol expressly dedicated to increasing access to cochlear implants to children in developing countries. However, the Global Foundation for Children with Hearing Loss (GFCHL) is one such organization thatâÂÂs passionately engaged with achieving this goal. Led by its Founder and Executive Director Page Stringer â a public health specialist and cochlear implant recipient herself â GFCHL has a mission to bring direct and lasting change for babies and young children who are deaf or hard of hearing and living in developing countries. Watch this video lasix protocol from Stringer to get a sense for the organization. According to Stringer. ÃÂÂA sustainable cochlear implant program in a country requires LOCALLY based expertise and services in cochlear implant surgery, audiology, cochlear implant mapping, auditory-verbal therapy, and early intervention. Not only do parents and family members need access to professional expertise and support, but they also need ongoing servicing lasix protocol and equipment. In many developing countries, these elements are lacking. There is also the high cost of all the elements, which makes it challenging for many families to afford if there is no insurance or government subsidy to support it.â Photo Courtesy of the Global Foundation For Children With Hearing Loss Stringer says that bringing hearing technology to children in developing countries is a two-fold effort. Raising lasix protocol awareness. Helping governments, local health administrations, caregivers, and the community at large understand that children with hearing loss can learn to listen and speak when they receive the proper support at an early enough stage. This is a process of educating and involving family members and caregivers while raising awareness among the general public. Organization and lasix protocol Logistics. Offering training programs that help developing countries establish local services and professional expertise. This is a process of showing countries how to develop screening programs that support early identification, encouraging timely fitting of hearing aids and cochlear implants, and ensuring access to locally-based professionals â such as audiologists, cochlear implant specialists, and speech therapists. With programs in Vietnam, Bhutan, and Mongolia, and previously in Ecuador, the efforts of GFCHL have lasix protocol made possible. The training of hundreds of teachers, therapists, and medical professionals Educational support about hearing loss in children for hundreds of families The fitting of over 400 children with digital hearing aids with ongoing support from professionals trained by GFCHL The GFCHL has also partnered with the global hearing care organization Hear the World Foundation (the charitable arm of Sonova that manufactures Advanced Bionics cochlear implants) to provide 10 Vietnamese children in need with cochlear implants along with 15 years of complimentary audiology support and technical upgrades. The children also receive complementary auditory-verbal therapy support by Vietnamese professionals trained by GFCHL for several years. Other organizations are also involved in providing hearing lasix protocol aid assistance to those in need. For example, key leadership from the affordable hearing aid manufacturer MDHearingAid (CEO Doug Breaker and VP of Product Sourcing Paul Bryant) recently helped sponsor the AllHear FoundationâÂÂs 2020 mission to Belize. The AllHear Foundation completed 100 free hearing tests and provided 91 free hearing aids to those in need. Image source lasix protocol. AllHear Foundation, Photos of Hearing Loss Patients in Belize, Photo Dr. Chip Goldsmith (Center Left) with Patient (Right) The Belize mission with AllHear Foundation was MDHearingAidâÂÂs first participation in an overseas project. Locally, MDHearingAid lasix protocol also partnered with H.O.M.E. To give away $100,000 worth of hearing aids to Chicago seniors in need. MDHearingAid says it will participate in more overseas and local missions to provide further hearing assistance in the future. Doug Breaker, MDHearing CEO lasix protocol commented, âÂÂGiving back is very important to us. Our mission is to provide affordable, high-quality hearing aids to as many people as possible. As part of that, we give to those in need whenever we can, and hope to expand those efforts in the future.â According to Stringer, overcoming the financial, organizational, and logistical challenges of providing hearing assistance to children in developing countries takes time. Nevertheless, the profound results of lasix protocol GFCHLâÂÂs efforts â and those of other organizations â can already be seen. (2) An Experimental Technology that Could Make Cochlear Implants More Accessible So far, weâÂÂve discussed how nonprofit groups are working to bring cochlear implants to more people around the world. However, there could be another way to boost access to cochlear implants even more. This involves a fundamental redesign of cochlear implant technology to make the devices more affordable to buy and the surgical lasix protocol techniques easier and safer to perform. We reached out to Dr. Chip Goldsmith, a neurotologist and cochlear implant surgeon who founded the nonprofit AllHear Foundation, to learn more about the latest in low-cost cochlear implant design. Goldsmith is working on an experimental â yet safer and more cost-effective â approach to cochlear implants lasix protocol. According to Goldsmith, the larger medical community views his approach with skepticism, but he believes that once fully developed and tested in patient trials, his design could dramatically improve access to cochlear implants for those living in low- to medium-income countries. GoldsmithâÂÂs ideas center around the question of whether the lasix protocol long, multi-channel electrode arrays in modern cochlear implants are necessary. Neurotologists usually agree that a multi-channel cochlear implant is required to stimulate key areas of the cochlea. Without this specific stimulation, they believe that perceiving speech and other complex sounds isnâÂÂt possible (see part one of this article to understand how conventional cochlear implants work). Unfortunately, the multi-channel requirement makes cochlear implants expensive to manufacture, and the surgery is invasive and difficult to lasix protocol perform. Moreover, inserting the long, multi-channel electrode array into the cochlea usually destroys any natural hearing ability the patient still has. According to Goldsmith, his late mentor, Dr. William F lasix protocol. House (who is credited as one of the inventors of cochlear implants), believed in a different approach to cochlear implant design. Dr. House maintained that a short, single-channel cochlear implant could serve as an affordable, less invasive lasix protocol solution to treat hearing loss. Goldsmith adds that âÂÂDr. House was known as the Father of Neurotology, and he was not too often wrong with his theories.â Image Source. Edited Image lasix protocol from Advanced Bionics As a continuation of Dr. HouseâÂÂs ideas, Goldsmith argues that we can achieve similar treatment results using a tiny cochlear implant with a short, single-channel electrode array, instead of a long, multi-channel array. Goldsmith alleges that â even with a short, single-channel implant â the brain has the ability to interpret sounds with sufficient clarity to understand speech and experience a rich complexity of sounds. Putting he and lasix protocol Dr. HouseâÂÂs theories into practice, Goldsmith has designed an affordable, single-channel cochlear implant that â after human trials and development â could retail for about $1,800, representing a considerable savings over the cost of conventional implants. The device is so tiny that the surgery for installing it is far less invasive and less complicated than traditional cochlear implant surgeries. Unlike conventional cochlear implants, installing the device would not pose lasix protocol a risk to the patientâÂÂs remaining hearing capabilities. Note the tiny size of GoldsmithâÂÂs single-channel implant compared to a multi-channel device. Image source. AllHear Foundation According to Goldsmith lasix protocol. ÃÂÂOur smaller and far less expensive cochlear implant system can be inserted through a simpler trans-canal surgical approach that goes through the ear canal and eardrum. This âÂÂtranstympanicâ procedure is safer than conventional cochlear implant surgeries because it does not require drilling through the mastoid bone or skull. We have lasix protocol also demonstrated that this procedure can be performed under local anesthesia.â Goldsmith also wanted to add the following. ÃÂÂI worked with Dr. House on his AllHear short electrode system for many years, and my AllHear Foundation is named after this implant. My transtympanic configuration is merely an offshoot of lasix protocol Dr. HouseâÂÂs fundamental theories.â At this time, GoldsmithâÂÂs team has built a new sound processor for single-channel implant recipients. Researchers are currently retrofitting patients who received one of Dr. HouseâÂÂs single-channel implants lasix protocol with this sound processor. If they can improve the hearing of these patients, they will adapt the new sound processor to fit Dr. GoldsmithâÂÂs transtympanic configuration. GoldsmithâÂÂs single-channel cochlear implant still requires extensive trials and testing â and the technology lasix protocol needs to gain acceptance and approval from the larger medical community. However, we spoke with Brandy Klann, MA, a cochlear implant audiologist at the Michigan Ear Institute who offered the following. "Dr. Goldsmith's ideas lasix protocol are intriguing. I look forward to seeing the clinical trial data on his single-channel cochlear implant." It is encouraging to see that certain medical innovators are working to make cochlear implants more affordable and accessible to everyone â especially when efforts like these are often hindered by a lack of funding and support from governments and the industry at large. Final Thoughts To think that the road to overcoming deafness and hearing loss began with scientists like Allessandro Volta, Giuseppe Veratti, and Benjamin Wilson sticking electrodes in their ears over 200 years ago â and to see where weâÂÂre at today â is absolutely inspiring. Considering what we've already achieved, the barriers to cochlear implant access in lasix protocol developing countries are not insurmountable. We have all the technology and organizational tools at our disposal to make this miraculous technology available to everyone â regardless of their economic status. All we need is the continued determination of organizations like the Global Foundation for Children with Hearing Loss, Hear the World Foundation, and AllHear Foundation, and innovative physicians like Dr. Chip Goldsmith, who are willing to think outside the box. Like a ripple effect, their efforts will bring transformative assistance to more children and adults with hearing loss, until eventually, no one is left behind. This article was sponsored in full by MDHearingAid, a hearing aid manufacturer that offers high-quality, affordable, FDA-registered hearing aids for a fraction of the cost of traditional aids. By selling its medical-grade hearing aids directly to consumers for just $399.98 to $999.99 a pair, MDHearingAid cuts out the middleman â transferring thousands of dollars in cost savings to its customers. This has opened the door to effective hearing loss treatment for millions of people who couldnâÂÂt previously afford to purchase hearing aids. If youâÂÂd like to support MDHearingAid in its mission to break the cost barriers associated with hearing loss treatment, tell your friends and family who need hearing aids about MDHearingAid and its affordable product line. Also, if you want to check your hearing to see if you could benefit from a pair of aids, click this link to take a free 5-minute hearing test from MDHearingAid now. Biography Fascinated by emerging science, Jeremy HillpotâÂÂs background in consumer litigation and technology offers a unique perspective on the latest developments in medical science, agrotechnology, blockchain, data engineering, app development, and the law. Contact Jeremy at jhillpot@legalwritingFINRA.com or follow him on Quora.. This article buy lasix 100mg contains affiliate links to products. Discover may receive a commission for purchases made through these links.Our liver plays a major role in supporting our overall health, including helping with the metabolic process, digestion, and proper blood circulation, as well as cleansing the body of harmful toxins. However, most people damage their livers without even knowing it, buy lasix 100mg with things like drinking too much alcohol, eating processed or fried foods, or even being just a little overweight. ThatâÂÂs why many people have been turning to natural liver health supplements. A good quality liver supplement is an effective solution to help repair liver damage and optimize liver functioning. Ranking the Best Liver Health Supplements On buy lasix 100mg The Market We reviewed the top brands and found the best 5 liver supplements on the market today. 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Their product is shown to aid liver function, metabolism, and whole-body buy lasix 100mg detoxification. LiverWell is best for those who need to reduce the effects of environmental toxins and struggle with metabolic issues. LiverWellâÂÂs use of powerful antioxidants has also been shown to reduce and repair damage done to liver and kidney health from free radicals in the body. Beyond that, LiveWell offers a comprehensive 365-day return policy, so everyone can try buy lasix 100mg their products completely risk-free. BUY HERE 3. Gaia Herbs Liver Cleanse Liver CleanseâÂÂs unique proprietary blend covers a vast range of liver supporting nutrients that are all-natural and entirely herbal. While it does contain milk thistle, it lacks several key ingredients, such as zinc, selenium, or any buy lasix 100mg form of Vitamin E. This limits its ability to support your liver health. The transparent labeling showcases all the ingredients included in its proprietary formula. Gaia Herbs takes a simple approach to producing a good quality liver support supplement for a low price range.Ask any nutritionist and they'll tell you that our health is a reflection of the lifestyle we lead and what we put on buy lasix 100mg our plates. The food we eat not only satisfies our hunger. It also fuels our bodies with energy to carry on. In todayâÂÂs buy lasix 100mg fast-paced life, there's limited time to make elaborate home-cooked meals. It's no wonder that 80 percent of Americans' total calorie consumption is thought to come from store-bought foods and beverages. Many of these food items are considered ua-processed, causing a growing rate of concern for human health among scientists.Breaking Down Ua-Processed FoodsYou may be wondering what exactly ua-processed foods are. The concept of processing refers to changing food buy lasix 100mg from its natural state, according to Harvard Health Publishing. Methods of accomplishing this include canning, smoking, pasteurizing and drying. Ua-processed foods take processing one step further by adding multiple ingredients such as sugar, preservatives and artificial flavors and colors. Commercially prepared cookies, chips and sodas are just a few of many examples buy lasix 100mg of foods that fall into the highly processed category. In order to further understand ua-processed foods, we must first explore the different levels of food processing. The term ua-processed was first coined by Carlos Monteiro, a professor of nutrition and public health at the University of Sao Paulo, Brazil. Monteiro also created a food classification system called buy lasix 100mg NOVA that has become a popular tool in categorizing different food items. The NOVA Food Classification system contains four different groups:Unprocessed/Minimally Processed Foods. Think 100 percent natural and healthy. This group includes foods such as buy lasix 100mg fruits, vegetables, eggs, meats and milk. Unprocessed foods are considered completely natural and are typically obtained directly from plants and animals. Minimally processed foods are also natural foods that have had very minor changes such as removal of inedible parts, fermentation, cooling, freezing, and any other processes that won't add extra ingredients or substances to the original product.Processed Culinary Ingredients. This group has everything to do with flavor and typically buy lasix 100mg contains ingredients such as fats and aromatic herbs that are extracted from natural foods. These ingredients are then used in homes and restaurants to season and cook items such as soups, salads and sweets. Many of these extracted ingredients can also be stored for later use. Processed Foods buy lasix 100mg. Most processed foods contain at least two or three added ingredients such as salt, sugar and oil. Think of this group as a combination of the first two groups. In other words, processed culinary ingredients or flavors buy lasix 100mg that are added to natural foods. Examples include fruits in sugar syrup, bacon, beef jerky and salted nuts. Ua-Processed Foods. Last and least healthy on the buy lasix 100mg NOVA scale are ua-processed foods. This group is considered highly processed due to a large amount of added ingredients. Nova typically classifies this group as industrial formulations made entirely or mostly from substances such buy lasix 100mg as oils, fats, sugar, starch and proteins as well as flavor enhancers and artificial colors that make these foods appear more attractive. Frozen items such as pre-prepared burgers or pizzas, candies, sodas, chips and ice cream are a few examples. On a daily basis, the ua-processed category is not the best source of your nutritional intake. But there's still hope for our frozen pizza and chocolate lovers buy lasix 100mg. Caroline Passerrello, spokesperson for the Academy of Nutrition and Dietetics, suggests that there may be a place on our plates for processed foods. Everything in ModerationIt's often said that most things are OK in moderation. But does this buy lasix 100mg saying ring true for ua-processed foods?. According to Passerrello, ua-processed foods like cookies, chips and sodas are more energy than nutrient-dense. This means that while the energy and calories are present, the nutrients we require like vitamins and minerals are often lacking. This can become a cause for concern because our bodies require buy lasix 100mg both energy and nutrients to function properly.A 2017 study that followed the dietary intakes of 9,317 participants found that Americans were eating ua-processed foods at alarming rates. Foods, in this case, were classified according to the NOVA scale. The results of the study showed that on average more than half of the calories of the participants came from ua-processed foods. These foods buy lasix 100mg failed to deliver proper nutrients. Participants that consumed more ua-processed food lacked proper protein, calcium, fiber, potassium, and vitamins A, C, D and E in their diets. In contrast, participants that consumed higher amounts of unprocessed or minimally processed foods had a better overall diet with adequate amounts of the different nutrients.So, a balanced diet of the different food groups may just be the way to go. But what happens when we overindulge in ua-processed foods on a regular buy lasix 100mg basis?. Because ua-processed foods are typically filled with sugar and fat, they've been linked to numerous health risks including obesity, heart disease and stroke, type-2 diabetes, cancer and depression.Passerrello explains that overconsumption of highly processed foods over time can also lead to vitamin and mineral deficiencies. In addition, processed foods tend to have higher amounts of sodium, which is often used to extend their shelf life. Consuming too much sodium can lead to feelings of dehydration and buy lasix 100mg cause muscle twitches.The health risks associated with overconsumption of ua-processed foods can easily pile up, but luckily, there are some healthy alternatives that we can choose to incorporate into our diet. Eat This Not ThatCutting down on ua-processed foods definitely seems like a good start to a healthy and balanced diet, but it's only the first step. "It's not just the ua-processed food itself that is the concern, but what else we are, or are not, eating â as well as what our bodies need and ultimately, what foods we have access to on a regular basis," says Passerrello.Health and nutrition can vary from person to person, so there is definitely no hard and fast rule as to what goes and what stays. However, Passerrello advises that if you are in a position in life with your time, taste and budget to make a choice between an ua-processed food item and a minimally processed food item, you buy lasix 100mg should typically opt for the minimally processed food.Yes, frozen dinners may be an easy option after a long day of work. However, an easy alternative that can save time could be meal prepping in advance. A homemade alternative such as a simple rice dish or burritos can be easy to make in batches and store away for the week. Another simple way to slowly decrease your intake of processed foods is to check food labels for excess amounts buy lasix 100mg of salt or sugar. Instead of sodas, Passerrello suggests opting for orange juice or milk that are fortified with calcium and vitamin D.Ultimately, choosing healthy foods is a matter of providing your body with the proper nutrients it needs while also incorporating your personal tastes and preferences. A handful of chips and a frozen pizza may not be the healthiest treat, but they won't do serious damage as long as ua-processed foods aren't your main and only form of nutrients.Like many people, Stephanie Holm made holiday cookies with her family last year. Her daughter found a recipe on the internet, and the two of them set to making them in the kitchen of their apartment.Together, they mixed the dough, rolled it out, put the cookies on a pan and popped it in the oven â âÂÂliterally covered in sprinkles on the outsideâ¦cute, and very delicious,â says Holm, a pediatric environmental medicine specialist at UC San Francisco.But as the cookies baked, Holm noticed that buy lasix 100mg the cute sugary coating burned a little in the oven, though not enough to ruin the cookies. Then Holm heard her daughter exclaim, âÂÂMama, itâÂÂs purple!. àand she saw that the air quality sensor she keeps in their apartment had indeed turned from green (good air quality) to purple (very unhealthy). Could a buy lasix 100mg single batch of slightly singed cookies have been to blame?. What happened with HolmâÂÂs cookies wasnâÂÂt a fluke. All cooking releases a complex mixture of chemicals, some of which would be classified as unhealthy pollutants. As for whether cooking buy lasix 100mg is hazardous to your health â the short answer is, it depends. But generally, if you have good ventilation, you should be fine.âÂÂWe all cook, and the average life expectancy is 78 or 79 years old. So we shouldnâÂÂt get too worried,â says Delphine Farmer, an atmospheric chemist at Colorado State University. ÃÂÂBut it is an opportunity to think about how to reduce your exposure to pollutants.âÂÂOut buy lasix 100mg of the Frying PanFarmerâÂÂs research found that cooking releases a mixture of hundreds of different chemical compounds into the air. Every ingredient gives off its own unique blend of particles and gases. Proteins in meat can break down and give off ammonia. Roasting can buy lasix 100mg produce isocyanates. Oils from frying and sautéing can aerosolize (thatâÂÂs how your counters end up with a fine layer of grease on them). The airborne molecules can continue to react and change as they drift around your kitchen and bump into each other.âÂÂYou can see some of these really interesting compounds,â Farmer says. ÃÂÂBut are they at levels that are toxic? buy lasix 100mg. We don't know.â Part of the uncertainty when it comes to health effects comes from the fact that most air quality studies and standards are based on outdoor air â despite our world where people today spend an estimated 90 percent of their time indoors. While Canada and the World Health Organization have indoor air quality guidelines, the U.S. Does not.In general, indoor air chemistry fluctuates a lot buy lasix 100mg more than outdoor air. The average air quality can be good, but as Holm and her daughter experienced, some activities â like cooking and cleaning â can cause dramatic changes. Pollutant levels will spike in the kitchen while cooking is actively happening and then drift back down as the airborne molecules disperse.âÂÂThe pattern of exposure is different. And we really don't have great scientific data on what the difference of that buy lasix 100mg pattern of exposures means for people's health.â Holm says.Acquiring that scientific data is no easy task. Variables that can affect cooking fumes and their contents include how often a person cooks, what they cook, how they cook it, what kind of appliance they use, what kind of ventilation they have and maybe even the type of pots and pans they use, says Iain Walker, an engineer at Lawrence Berkeley National Lab who studies home air quality and ventilation. The best researchers can do is try to gauge the relative impact of each factor. Gas stove buy lasix 100mg or electric?. Boiling or frying?. Meat buy lasix 100mg or vegetables?. Nonstick pan or stainless steel?. Into the FireThe main pollutant of concern linked to cooking is particulate matter. This catchall term refers to a complex mix of microscopic buy lasix 100mg solid bits and uafine liquid droplets that could be made up of hundreds of different chemical compounds. The chemistry doesnâÂÂt matter nearly as much as the size. Particles smaller than 10 microns (less than 1/5 the width of a human hair) can make their way into the lungs and lodge there. Even smaller particles can make their way into the bloodstream.Particulate matter is the reason buy lasix 100mg you donâÂÂt want to breathe in smoke or car exhaust. Chronic exposure to high levels of particulate matter exacerbates asthma, but also makes it more likely that a child will develop asthma, says Holm. ItâÂÂs also linked to changes in childhood growth, metabolism and brain development, and itâÂÂs classified as a carcinogen by the WHO.All cooking produces some particulate matter in the form of aerosols and tiny bits of char generated from food and dust being heated up. If you can smell burning, youâÂÂre likely buy lasix 100mg breathing in quite a bit of particulate matter. ÃÂÂAnything with a red-hot element is going to generate particles,â says Walker. That includes most stovetops, ovens and even small appliances like toasters. Frying and roasting cook methods both produce a lot more particulate buy lasix 100mg matter than boiling or steaming. And fatty foods give off more than veggies.Gas stoves are particularly bad for indoor air quality. Not only do they produce more particulate matter by virtue of creating an open flame, but the actual fossil fuel combustion also generates other gases, such as carbon dioxide and nitrogen dioxide. From a health perspective, the thing that raises the biggest concern in this scenario is nitrogen dioxide.Nitrogen dioxide, like particulate matter, contributes to breathing buy lasix 100mg problems like asthma and is regulated in outdoor air. The gas has also been linked to heart problems, lower birth weight in newborns and shorter lifespans for people who are chronically exposed.A 2016 study from Lawrence Berkeley National Lab found that simply boiling water on a gas stove produces nearly twice the amount of nitrogen dioxide as the EPAâÂÂs outdoor standard. Considering that about a third of American homes use natural gas for cooking, thatâÂÂs a lot of potential exposure.âÂÂSomehow, we've just become used to an unvented fossil fuel device in our homes,â says Brady Seals, who manages the carbon-free buildings program at the Rocky Mountain Institute, a clean energy think tank. She wants to raise awareness of nitrogen dioxideâÂÂs health risks as a way to buy lasix 100mg discourage natural gas use in homes. And sheâÂÂs not alone in this mission. The Massachusetts Medical Society passed a resolution in 2019 to recognize the link between gas stoves and pediatric asthma. Several cities in California, including San Francisco, have passed bans on natural gas in new construction, citing both climate and health hazards.If you have a gas cooktop, Seals and Walker recommend swapping it out for an electric one if you have the means and ability buy lasix 100mg to do so. ÃÂÂNot only are you reducing carbon impact [on the environment], but you can have a healthier home if you get rid of combustion appliances,â Walker says.The best option from both an energy-efficiency and air-quality perspective, he says, is an induction stove, which uses magnets to transfer heat directly to your pots and pans. No red-hot elements means less particulate matter. If you canâÂÂt replace your gas stove, Seals recommends a plug-in induction cooktop.Vented AirRealistically, few people are going to swear off stir frying buy lasix 100mg or using their oven for the sake of producing less particulate matter. ÃÂÂEverybodyâÂÂs going to cook what theyâÂÂre going to cook,â says Farmer, noting that people use whatever kitchen appliances they have. ThatâÂÂs why all these experts stress the importance of good ventilation.Holm was part of a 2018 study looking at particulate matter in the homes of children with asthma. One of the most surprising findings buy lasix 100mg. In homes that never used a range hood or range fan, people were exposed to unhealthy levels of particulate matter for roughly 10 percent more time than in homes that used range ventilation.Walker, the ventilation expert, recommends that people should use a high setting on their kitchen range hood whenever possible, since the quieter low settings capture only about half of pollutants. Since most range hoods donâÂÂt extend over the front burners, you might want to consider using the back burners, especially if you have a gas stove. Walker also advises that people keep the ventilation on for about 15 minutes after theyâÂÂre done cooking buy lasix 100mg. ThatâÂÂs about how long it takes for all of the air in the room to be replaced. But that only applies if your vent is sending fumes outside, which is not often the case.Unless you have a new, higher-end kitchen and stove, your built-in range ventilation might essentially be a fan. ItâÂÂs just pushing the fumes around the room, which helps disperse the concentration buy lasix 100mg of pollutants more quickly but doesnâÂÂt actually remove them from your house. Many homes and apartments, including HolmâÂÂs, donâÂÂt even have that option. In that case, Holm recommends opening some windows if the outside air quality is good, or using a portable air purifier with a HEPA filter.In the end, there are still a lot of unknowns about how cooking fumes affect us. To some extent, we simply have buy lasix 100mg to accept them as a byproduct of enjoying our favorite foods, much like we accept pet hair as a part of having a furry friend. ÃÂÂYou start realizing how pollutants are a part of our life,â Seals says. ÃÂÂLetâÂÂs reduce pollution wherever we can. But IâÂÂm not going to give up my dog and IâÂÂm not going to stop buy lasix 100mg cooking.âÂÂ[Correction. A previous version of this story erroneously stated the findings of Holm's 2018 air quality study and the type of portable air purifier that Holm recommends using in homes. We apologize for the errors, which have been corrected in this current version.]A happy accident with a chocolate bar led to one of the most reliable kitchen appliances around today. Engineer Percy Spencer was standing in front of buy lasix 100mg a device emitting high-frequency radio waves when the chocolate in his shirt pocket began to melt. The change led him and his colleagues to investigate what electromagnetic radiation could do to food, and the microwave was born in 1947.Since its earliest days, the technology has gotten smaller and lighter, and the kind of radiation used has shifted. SpencerâÂÂs discovery happened with radio waves, and the devices now rely on microwave radiation to cook our meals. Despite the changes â and how permanent a fixture microwaves have become in households â some people are still uneasy around the devices and worry about potential buy lasix 100mg health effects. ÃÂÂAs a professor working in this area, safety is important to me,â says Vijaya Raghavan, a bioresource engineer at McGill University, who studies how industrial microwave settings can pasteurize and sterilize foods. Luckily, a lot of the safety concerns are handled by regulations, and there are simple ways for people to minimize the very small risks they face.Microwaves Bring the HeatMicrowaves are a kind of radiation, just like infrared, visible light, and x-rays. They are buy lasix 100mg also relatively large. In terms of size and speed, microwaves are more like radio waves than they are the kind of light we see. Put to buy lasix 100mg work inside kitchen appliances, the radiation is useful for cooking food fast. Microwaves emit from one side of the appliance while itâÂÂs running and bounce around, reflecting off the metal interior and going into your meal. There, microwaves force all the water molecules in your food to move. The spinning water molecules generate heat and voila buy lasix 100mg â your leftovers, vegetables or frozen dinner gets cooked.When it comes to making water molecules spin and create heat, microwaves donâÂÂt discriminate. TheyâÂÂll do the same to your arm or leg, which is why microwave exposure can be dangerous. Exposure can burn skin. Eyes and testicles are particularly vulnerable, according to the Food and Drug Administration, because thereâÂÂs relatively little blood flow in the buy lasix 100mg area to carry away the building heat. Highly-Controlled and Low RiskHowever, microwave burns only happen after someone has had a lot of exposure to the radiation â which is not something that will happen from your microwave oven. For one, microwaves can only operate if the door is closed, per FDA requirements. As soon as it opens, the radiation production buy lasix 100mg stops. Any microwaves that were still within the device dissipate into the air right away, Raghavan says. Theoretically, a tiny bit of the microwaves could leak out of any cracks, like where the door shuts. But the buy lasix 100mg FDA regulates seeping radiation, too. The amount of microwave radiation the agency lets the kitchen appliances emit is significantly less than how much cell phones are allowed to release â and the levels our smartphones can generate are also considered safe. And because any radiation coming out of an operating microwave starts to fall apart very quickly, someone would have to be standing practically up against the microwave for a long time for the rays to cause any damage. Sure, the farther away from the microwave you are, the safer it is, buy lasix 100mg Raghavan says. ÃÂÂBut if youâÂÂre certain that a microwave unit is being used, why do you want to stand next to it anyways?. ÃÂÂIn his own lab, Raghavan uses all kinds of microwave ovens to see how they can help with industrial food preparation. He often buy lasix 100mg buys standard microwaves most people put in their homes and reworked them to create the wavelength frequency he needs. Raghavan also keeps track of how much power is generated in the first place as well as how much of the microwaves are absorbed by the food or reflected. Even in this laboratory setting, he and his colleagues donâÂÂt wear protective gear. Instead, they put leakage buy lasix 100mg meters near the devices. People at home probably donâÂÂt need to stand right next to the microwave, as Raghavan points out. Also, donâÂÂt run it without anything inside. The microwaves will bounce buy lasix 100mg back and damage the internal mechanisms that help transmit the microwaves, Raghavan says. And if you find your microwave keeps running once you open the door, remove it and get a new model â you donâÂÂt want to be Percy Spencer and find that radiation is melting your pocket chocolate.Part one of this article began with a light-hearted anecdote about Count Volta sticking electrodes in his ears. Part two takes a more serious tone. Here, we address the reasons why cochlear implants arenâÂÂt available to everyone, and why they are nearly inaccessible to those who need them most in the developing world buy lasix 100mg. The most pressing barriers that prevent adults and children in developing countries from accessing the benefits of cochlear implants are plain enough. (1) the high cost of cochlear implant components. (2) the buy lasix 100mg complexity and skill level required to perform the surgery. And (3) the lack of local post-operative rehab services and expertise. Fortunately, thereâÂÂs a light at the end of the tunnel. In part two of this article, we look at the tremendous efforts of nonprofit groups to overcome these buy lasix 100mg barriers to cochlear implants in developing countries. We also look at an experimental (yet controversial) approach to cochlear implants that could dramatically reduce the cost and complexity of implant components and surgeries. Why Access to Cochlear Implants Is So Important for Children Cochlear implants can offer life-transforming help to adults with hearing loss, but they are even more important for children. ThatâÂÂs because children with hearing loss have a limited buy lasix 100mg period of time in which to develop speech and listening skills. If a hearing problem isnâÂÂt addressed with hearing aids or cochlear implants by the age of 3 (and preferably earlier), children with serious hearing conditions may not be able to develop auditory and speech skills naturally. Without listening and spoken language skills, it is more difficult for children with deafness and profound hearing loss to attend mainstream school or fully participate in their hearing communities. Tragically, many of these children in developing nations buy lasix 100mg are miscategorized as intellectually disabled â when in fact, there is a shining, beautiful mind hidden behind their inability to communicate. Photo Courtesy of the Global Foundation For Children With Hearing Loss According to Paige Stringer, Executive Director of the Global Foundation For Children With Hearing Loss (GFCHL). ÃÂÂIt is essential that hearing loss be identified as early as possible in newborns and young children so they can get the hearing technology and early intervention support they need to learn to listen and speak. For a child to develop buy lasix 100mg on par with typically hearing peers in the areas of speech, language, and audition, they must have access to the sounds of speech. Early access to hearing aids or cochlear implants is key for successful outcomes.â A landmark 2010 study echoes StringerâÂÂs perspective by confirming what most in the hearing and speech-language professions already knew. The study found that children who receive cochlear implants before the age of 18 months achieved a speaking ability closer to that of hearing children. In contrast, those who received cochlear implants after the age of 3 continued to exhibit certain gaps in speaking ability buy lasix 100mg compared to children without hearing loss. In developing countries, where access to cochlear implants and hearing aids is scarce, some deaf children may be able to attend schools where they can learn sign language and benefit from a specialized curriculum. But children in rural, undeveloped areas donâÂÂt tend to have this option. Without cochlear implants, access to affordable hearing aids, or proper schooling, these children may not be able to develop their language and communication skills buy lasix 100mg in a mainstreamed environment. To say that these children face severe discrimination, social isolation, and extreme socio-economic challenges as a result of their hearing difficulties would be an understatement. Image source. BBC When children are born with hearing impairment and deafness in developed countries like the United States or the United Kingdom, technologies, therapies, and educational buy lasix 100mg opportunities are more readily available and help to remove the barriers to living a normal life. These children have the potential to grow up without impediments as developing children typically do. Why Are Cochlear Implants buy lasix 100mg Difficult to Access in Developing Countries?. There are three main reasons why cochlear implants are difficult to access in developing countries. (1) the cost of the components and surgeries. (2) the complexity and surgical skill required buy lasix 100mg to perform the procedures. And, (3) the need for post-operative rehabilitation services. (1) The High Cost of Cochlear Implant Components The cost of cochlear implant components and surgeries depends on a number of factors, but one thing is certain. The prices far exceed buy lasix 100mg what the average person in a developing country can afford. In the United States, the components alone â without factoring in surgical costs â can exceed $25,000 per ear, and total costs with surgery can exceed $80,000 per ear. In developed nations, private or national insurance usually covers these costs, so access isnâÂÂt an issue. In many Asian, African, and Latin American countries, buy lasix 100mg the cost of cochlear implant components is less, but the prices are still prohibitively high. In the article, âÂÂThe Challenges of Starting a Cochlear Implant Programme in a Developing Country,â Dr. Kumaresh Krishnamoorthy writes that Cochlear Implant components cost from $12,000 to $25,000 in India. With surgery, buy lasix 100mg total costs come to $17,000 to $29,500. If you consider that the average Indian salary is $2,120 per year â and that these individuals are living paycheck to paycheck â itâÂÂs easy to see why cochlear implants are absolutely unaffordable for most Indians without any available government or insurance financial support. According to Stringer. ÃÂÂThere are also buy lasix 100mg the ongoing costs associated with cochlear implants after surgery â which includes a lifelong commitment to paying for post-op rehabilitation, replacement parts, servicing, and upgrades. Many families focus on the cost of the initial device and surgery, but they donâÂÂt have the means to pay for these ongoing costs.â As Krishnamoorthy points out. ÃÂÂCochlear implants are a proven auditory rehabilitative option for individuals with severe to profound sensorineural hearing loss, who otherwise do not benefit from hearing aids. Nevertheless, only a small percentage of these individuals receive cochlear implants, and cost remains a leading prohibitive factor, particularly in developing countries buy lasix 100mg [â¦] the technology is virtually unavailable to the masses.â Unfortunately, even though many developing countries have government-sponsored cochlear implant programs, most do not have enough surgeons or facilities â or rehabilitation support post-surgery â to service all of the people who need them. (2) The Complexity and Skill Level Required to Perform Cochlear Implant Surgeries Once fully trained, a neurotologist can safely perform a cochlear implant procedure, but the surgical training is long, involved, and expensive â and itâÂÂs only available in developed countries. As a result, there are not enough surgeons in developing countries who can safely perform cochlear implant procedures. Image Source buy lasix 100mg. Blausen.com staff (2014). ÃÂÂMedical gallery of Blausen Medical 2014âÂÂ. WikiJournal of buy lasix 100mg Medicine 1 (2). DOI:10.15347/wjm/2014.010. ISSN 2002-4436. When you see buy lasix 100mg the steps involved, itâÂÂs easy to understand the complexity of the procedure. Administer general anesthesia. General anesthesia is required during the two- to four-hour procedure. Make an incision behind the ear buy lasix 100mg. The surgeon makes an incision behind the ear to expose the mastoid bone. Identify the facial nerves. The surgeon finds the buy lasix 100mg facial nerves and drills an opening between them through the mastoid bone to expose the cochlea. Place the electrode array. The surgeon opens the cochlea and threads the electrode array into the cochlea. Place buy lasix 100mg the receiver. The surgeon makes a shallow indentation into the skull behind the ear and fixes the round, flat receiver into the bone just beneath the ear. Close the incisions. The surgeon buy lasix 100mg closes the incisions and the procedure is complete. Considering these steps, the cochlear implant procedure is neither âÂÂsimpleâ nor âÂÂeasyâ to perform. It requires general anesthesia, drilling through the mastoid bone, and the removal of a portion of the skull. There is also the risk buy lasix 100mg of facial nerve damage. While the use of surgical robots for cochlear implant procedures could reduce the skill requirement, this technology is still largely inaccessible in developing countries. As we will discuss in further detail below, there is the possibility that an experimental cochlear implant design could one day reduce the cost and surgical complexity associated with this technology. (3) The Need for Post-Operative buy lasix 100mg Rehabilitation and Training Beyond the cost and complexity of cochlear implant surgeries, implant recipients need several months â or years in the case of infants and young children â of training as they learn to recognize sounds and understand speech. For children, speech-language therapy is particularly important. This training requirement often prevents those living in rural areas from getting cochlear implants â simply because they cannot access an in-person therapist for post-op rehab and speech-language training. Stringer from GFCHL offered the following perspectives on this buy lasix 100mg. ÃÂÂCochlear implant technology is not a stand-alone solution. It is an intensive medical device buy lasix 100mg that needs a lot of support. CIs are not like glasses where you put them on and instantly see better. A CI is just a tool to enable access to the sounds of speech. There is a great deal of rehabilitation involved after the CI surgery, particularly in young children, to fully benefit from it.â Getting cochlear implants to those who need them isnâÂÂt just a question of funding and buy lasix 100mg sourcing surgeons. To make this technology available to more people in developing countries, national governments also need to conquer the serious logistical challenge of building a medical infrastructure that (1) has enough skilled surgeons and surgical facilities to serve everyone. And (2) has enough local training facilities where cochlear implant recipients can receive post-operative rehab and speech-language therapy. (4) The Lack of Awareness Surrounding the Benefits of Cochlear Implants There is also a lack of awareness surrounding (1) the need to screen babies and young children for signs of deafness, and (2) the benefits of cochlear implants and hearing aids when treating deafness and other hearing conditions buy lasix 100mg. Without a general understanding of these issues, children born with hearing loss may never be identified â and even if they are identified, parents may not be aware that treatments and therapies are available. As for adults with hearing loss, they also might not realize that they are suffering from hearing loss â and if they do realize it, they might not know that a pair of hearing aids or cochlear implants can dramatically improve their lives. Incidentally, this lack of awareness is also a problem in the developed world, but adults â no matter where they are â can quickly assess their level of hearing loss by taking a free online hearing buy lasix 100mg test. If youâÂÂre curious to check your hearing, hereâÂÂs a free, 5-minute hearing test from MDHearingAid. Overcoming the Challenges of Cochlear Implant Access The most common approach to overcoming the lack of access to cochlear implants is to increase nonprofit support and international aid for government cochlear implant programs. This involves helping developing nations buy lasix 100mg overcome the logistical challenges of sourcing surgeons, establishing surgical and post-operative facilities, and educating the public on hearing loss treatment options. A second approach to increasing access involves a radical rethinking of the technology and its surgical techniques. By redesigning cochlear implants to be more affordable â and making surgeries simpler and less invasive â overcoming the cost and logistical challenges of cochlear implants becomes a great deal easier. (1) Nonprofit Efforts to Boost Cochlear Implant Access in Developing Countries There arenâÂÂt many organizations expressly dedicated to increasing access to cochlear implants to children in developing countries buy lasix 100mg. However, the Global Foundation for Children with Hearing Loss (GFCHL) is one such organization thatâÂÂs passionately engaged with achieving this goal. Led by its Founder and Executive Director Page Stringer â a public health specialist and cochlear implant recipient herself â GFCHL has a mission to bring direct and lasting change for babies and young children who are deaf or hard of hearing and living in developing countries. Watch this buy lasix 100mg video from Stringer to get a sense for the organization. According to Stringer. ÃÂÂA sustainable cochlear implant program in a country requires LOCALLY based expertise and services in cochlear implant surgery, audiology, cochlear implant mapping, auditory-verbal therapy, and early intervention. Not only do parents and family members need access to professional expertise and support, but they also need ongoing buy lasix 100mg servicing and equipment. In many developing countries, these elements are lacking. There is also the high cost of all the elements, which makes it challenging for many families to afford if there is no insurance or government subsidy to support it.â Photo Courtesy of the Global Foundation For Children With Hearing Loss Stringer says that bringing hearing technology to children in developing countries is a two-fold effort. Raising buy lasix 100mg awareness. Helping governments, local health administrations, caregivers, and the community at large understand that children with hearing loss can learn to listen and speak when they receive the proper support at an early enough stage. This is a process of educating and involving family members and caregivers while raising awareness among the general public. Organization and buy lasix 100mg Logistics. Offering training programs that help developing countries establish local services and professional expertise. This is a process of showing countries how to develop screening programs that support early identification, encouraging timely fitting of hearing aids and cochlear implants, and ensuring access to locally-based professionals â such as audiologists, cochlear implant specialists, and speech therapists. With programs in Vietnam, Bhutan, and Mongolia, and previously in Ecuador, the efforts of GFCHL have made possible buy lasix 100mg. The training of hundreds of teachers, therapists, and medical professionals Educational support about hearing loss in children for hundreds of families The fitting of over 400 children with digital hearing aids with ongoing support from professionals trained by GFCHL The GFCHL has also partnered with the global hearing care organization Hear the World Foundation (the charitable arm of Sonova that manufactures Advanced Bionics cochlear implants) to provide 10 Vietnamese children in need with cochlear implants along with 15 years of complimentary audiology support and technical upgrades. The children also receive complementary auditory-verbal therapy support by Vietnamese professionals trained by GFCHL for several years. Other organizations are buy lasix 100mg also involved in providing hearing aid assistance to those in need. For example, key leadership from the affordable hearing aid manufacturer MDHearingAid (CEO Doug Breaker and VP of Product Sourcing Paul Bryant) recently helped sponsor the AllHear FoundationâÂÂs 2020 mission to Belize. The AllHear Foundation completed 100 free hearing tests and provided 91 free hearing aids to those in need. Image buy lasix 100mg source. AllHear Foundation, Photos of Hearing Loss Patients in Belize, Photo Dr. Chip Goldsmith (Center Left) with Patient (Right) The Belize mission with AllHear Foundation was MDHearingAidâÂÂs first participation in an overseas project. Locally, MDHearingAid also partnered buy lasix 100mg with H.O.M.E. To give away $100,000 worth of hearing aids to Chicago seniors in need. MDHearingAid says it will participate in more overseas and local missions to provide further hearing assistance in the future. Doug Breaker, MDHearing CEO commented, âÂÂGiving back is very buy lasix 100mg important to us. Our mission is to provide affordable, high-quality hearing aids to as many people as possible. As part of that, we give to those in need whenever we can, and hope to expand those efforts in the future.â According to Stringer, overcoming the financial, organizational, and logistical challenges of providing hearing assistance to children in developing countries takes time. Nevertheless, the profound results of GFCHLâÂÂs efforts â and those of other organizations â can already buy lasix 100mg be seen. (2) An Experimental Technology that Could Make Cochlear Implants More Accessible So far, weâÂÂve discussed how nonprofit groups are working to bring cochlear implants to more people around the world. However, there could be another way to boost access to cochlear implants even more. This involves a fundamental redesign of cochlear implant technology to make the devices more affordable to buy and the surgical techniques easier and safer buy lasix 100mg to perform. We reached out to Dr. Chip Goldsmith, a neurotologist and cochlear implant surgeon who founded the nonprofit AllHear Foundation, to learn more about the latest in low-cost cochlear implant design. Goldsmith is working on an experimental â yet safer and more cost-effective â approach to cochlear buy lasix 100mg implants. According to Goldsmith, the larger medical community views his approach with skepticism, but he believes that once fully developed and tested in patient trials, his design could dramatically improve access to cochlear implants for those living in low- to medium-income countries. GoldsmithâÂÂs ideas center around the question of whether the long, multi-channel electrode arrays in modern cochlear implants are buy lasix 100mg necessary. Neurotologists usually agree that a multi-channel cochlear implant is required to stimulate key areas of the cochlea. Without this specific stimulation, they believe that perceiving speech and other complex sounds isnâÂÂt possible (see part one of this article to understand how conventional cochlear implants work). Unfortunately, the multi-channel requirement makes buy lasix 100mg cochlear implants expensive to manufacture, and the surgery is invasive and difficult to perform. Moreover, inserting the long, multi-channel electrode array into the cochlea usually destroys any natural hearing ability the patient still has. According to Goldsmith, his late mentor, Dr. William F buy lasix 100mg. House (who is credited as one of the inventors of cochlear implants), believed in a different approach to cochlear implant design. Dr. House maintained that a short, buy lasix 100mg single-channel cochlear implant could serve as an affordable, less invasive solution to treat hearing loss. Goldsmith adds that âÂÂDr. House was known as the Father of Neurotology, and he was not too often wrong with his theories.â Image Source. Edited Image from Advanced Bionics buy lasix 100mg As a continuation of Dr. HouseâÂÂs ideas, Goldsmith argues that we can achieve similar treatment results using a tiny cochlear implant with a short, single-channel electrode array, instead of a long, multi-channel array. Goldsmith alleges that â even with a short, single-channel implant â the brain has the ability to interpret sounds with sufficient clarity to understand speech and experience a rich complexity of sounds. Putting he and buy lasix 100mg Dr. HouseâÂÂs theories into practice, Goldsmith has designed an affordable, single-channel cochlear implant that â after human trials and development â could retail for about $1,800, representing a considerable savings over the cost of conventional implants. The device is so tiny that the surgery for installing it is far less invasive and less complicated than traditional cochlear implant surgeries. Unlike conventional cochlear implants, installing the device would buy lasix 100mg not pose a risk to the patientâÂÂs remaining hearing capabilities. Note the tiny size of GoldsmithâÂÂs single-channel implant compared to a multi-channel device. Image source. AllHear Foundation According to Goldsmith buy lasix 100mg. ÃÂÂOur smaller and far less expensive cochlear implant system can be inserted through a simpler trans-canal surgical approach that goes through the ear canal and eardrum. This âÂÂtranstympanicâ procedure is safer than conventional cochlear implant surgeries because it does not require drilling through the mastoid bone or skull. We have also demonstrated that this procedure can be performed under local buy lasix 100mg anesthesia.â Goldsmith also wanted to add the following. ÃÂÂI worked with Dr. House on his AllHear short electrode system for many years, and my AllHear Foundation is named after this implant. My transtympanic configuration is merely an offshoot of buy lasix 100mg Dr. HouseâÂÂs fundamental theories.â At this time, GoldsmithâÂÂs team has built a new sound processor for single-channel implant recipients. Researchers are currently retrofitting patients who received one of Dr. HouseâÂÂs single-channel implants with this sound processor buy lasix 100mg. If they can improve the hearing of these patients, they will adapt the new sound processor to fit Dr. GoldsmithâÂÂs transtympanic configuration. GoldsmithâÂÂs single-channel cochlear implant still requires extensive trials and testing â buy lasix 100mg and the technology needs to gain acceptance and approval from the larger medical community. However, we spoke with Brandy Klann, MA, a cochlear implant audiologist at the Michigan Ear Institute who offered the following. "Dr. Goldsmith's ideas buy lasix 100mg are intriguing. I look forward to seeing the clinical trial data on his single-channel cochlear implant." It is encouraging to see that certain medical innovators are working to make cochlear implants more affordable and accessible to everyone â especially when efforts like these are often hindered by a lack of funding and support from governments and the industry at large. Final Thoughts To think that the road to overcoming deafness and hearing loss began with scientists like Allessandro Volta, Giuseppe Veratti, and Benjamin Wilson sticking electrodes in their ears over 200 years ago â and to see where weâÂÂre at today â is absolutely inspiring. Considering what we've already achieved, the barriers to cochlear implant access in developing countries are not buy lasix 100mg insurmountable. We have all the technology and organizational tools at our disposal to make this miraculous technology available to everyone â regardless of their economic status. All we need is the continued determination of organizations like the Global Foundation for Children with Hearing Loss, Hear the World Foundation, and AllHear Foundation, and innovative physicians like Dr. Chip Goldsmith, who are willing buy lasix 100mg to think outside the box. Like a ripple effect, their efforts will bring transformative assistance to more children and adults with hearing loss, until eventually, no one is left behind. This article was sponsored in full by MDHearingAid, a hearing aid manufacturer that offers high-quality, affordable, FDA-registered hearing aids for a fraction of the cost of traditional aids. By selling its medical-grade hearing aids directly to consumers for just $399.98 to $999.99 a pair, MDHearingAid cuts out the middleman â transferring thousands of dollars in cost savings to its customers. This has opened the door to effective hearing loss treatment for millions of people who couldnâÂÂt previously afford to purchase hearing aids. If youâÂÂd like to support MDHearingAid in its mission to break the cost barriers associated with hearing loss treatment, tell your friends and family who need hearing aids about MDHearingAid and its affordable product line. Also, if you want to check your hearing to see if you could benefit from a pair of aids, click this link to take a free 5-minute hearing test from MDHearingAid now. Biography Fascinated by emerging science, Jeremy HillpotâÂÂs background in consumer litigation and technology offers a unique perspective on the latest developments in medical science, agrotechnology, blockchain, data engineering, app development, and the law. Contact Jeremy at jhillpot@legalwritingFINRA.com or follow him on Quora.. |
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